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| Name | Class |
|---|---|
| LanZhou University | OTHER |
| Tianjin Second People's Hospital | OTHER |
| The First Affiliated Hospital with Nanjing Medical University | OTHER |
| People's Hospital of Ningxia Hui Autonomous Region |
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The presence of varices is a serious complication of portal hypertension in liver disease. To prevent variceal haemorrhage, screening and surveillance aims to detect high-risk varices related to varices size and determine the need for primary prophylaxis. Varices size evaluated by endoscopists might not be perfect reference, influenced by experience and machine. Endoscopic ruler is a novel tool to measure the varices size under the endoscopy. The investigators aim to evaluate the bias of varices size between endoscopists and endoscopic ruler as the reference.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Overall eligible participants | Eligible participants whose varix size will be measured by endoscopists and endoscopic ruler will receive standard esophagogastroduodenoscopy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endoscopic ruler | Diagnostic Test | Endoscopic ruler for varices in portal hypertension Product uses: measuring the diameter of the veins under the endoscopy for the assessment of the risk of variceal haemorrhage in patients with portal hypertension Black and white measuring rule is highly recognizable under the endoscopy The width of each cell is 1 mm, and the measuring range is 0-10 mm With smooth edge, safe and reliable |
| Measure | Description | Time Frame |
|---|---|---|
| The intraclass correlation coefficient (ICC) of the varix size and the kappa value of the varices bleeding risk between endoscopists and endoscopic ruler | 2020/11/13-2022/11/13 |
| Measure | Description | Time Frame |
|---|---|---|
| The ICC value of the varix size and the kappa value of the varices bleeding risk among endoscopists | 2020/11/13-2022/11/13 | |
| The bleeding rate of endoscopic ruler | 2020/11/13-2022/11/13 | |
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Inclusion Criteria:
Exclusion Criteria:
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The investigators prospectively recruit well-defined participants with liver cirrhosis from university hospitals. Esophagogastroduodenoscopy is performed by a dedicated endoscopist at each center. Varices size is evaluated by the endoscopist and endoscopic ruler.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaolong Qi, M.D. | Contact | +86 18588602600 | qixiaolong@vip.163.com | |
| Yifei Huang, M.D. | Contact | +86 15800004518 | huangyf1995@foxmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiaolong Qi, M.D. | LanZhou University | Study Chair |
| Fengmei Wang, M.D. | Tianjin Second People's Hospital | Principal Investigator |
| Guoxin Zhang, M.D. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Affiliated Hospital of Baotou Medical College | Not yet recruiting | Baotou | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30215362 | Background | Qi X, Berzigotti A, Cardenas A, Sarin SK. Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension. Lancet Gastroenterol Hepatol. 2018 Oct;3(10):708-719. doi: 10.1016/S2468-1253(18)30232-2. | |
| 25177367 | Background | Cremers I, Ribeiro S. Management of variceal and nonvariceal upper gastrointestinal bleeding in patients with cirrhosis. Ther Adv Gastroenterol. 2014 Sep;7(5):206-16. doi: 10.1177/1756283X14538688. |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| OTHER |
| The Second Affiliated Hospital of Baotou Medical College | OTHER |
| The Third Xiangya Hospital of Central South University | OTHER |
| The Second Hospital of Hebei Medical University | OTHER |
| The Affiliated Hospital Of Southwest Medical University | OTHER |
| First Hospital of China Medical University | OTHER |
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|
| The timing of endoscopic ruler |
| 2020/11/13-2022/11/13 |
| The correlation coefficient between varices size and hepatic venous pressure gradient | 2020/11/13-2022/11/13 |
| The correlation coefficient between varices size and decompensated events | 2020/11/13-2022/11/13 |
| The First Affiliated Hospital with Nanjing Medical University |
| Principal Investigator |
| Shengjuan Hu, M.D. | People's Hospital of Ningxia Hui Autonomous Region | Principal Investigator |
| Xianmei Meng, M.D. | The Second Affiliated Hospital of Baotou Medical College | Principal Investigator |
| Xiaoyan Wang, M.D. | The Third Xiangya Hospital of Central South University | Principal Investigator |
| Zhijie Feng, M.D. | The Second Hospital of Hebei Medical University | Principal Investigator |
| Muhan Lv, M.D. | The Affiliated Hospital Of Southwest Medical University | Principal Investigator |
| Yiling Li, M.D. | First Hospital of China Medical University | Principal Investigator |
| The Third Xiangya Hospital of Central South University | Not yet recruiting | Changsha | China |
|
| The first hospital of Lanzhou university | Not yet recruiting | Lanzhou | China |
|
| The First Affiliated Hospital with Nanjing Medical University | Not yet recruiting | Nanjing | China |
|
| The Second Hospital of Hebei Medical University | Not yet recruiting | Shijiazhuang | China |
|
| Tianjin Second People's Hospital | Not yet recruiting | Tianjin | China |
|
| People's Hospital of Ningxia Hui Autonomous Region | Recruiting | Yinchuan | China |
|
| 2312048 | Background | Bendtsen F, Skovgaard LT, Sorensen TI, Matzen P. Agreement among multiple observers on endoscopic diagnosis of esophageal varices before bleeding. Hepatology. 1990 Mar;11(3):341-7. doi: 10.1002/hep.1840110302. |
| 2203663 | Background | Cales P, Pascal JP. Gastroesophageal endoscopic features in cirrhosis: comparison of intracenter and intercenter observer variability. Gastroenterology. 1990 Oct;99(4):1189. doi: 10.1016/0016-5085(90)90652-h. No abstract available. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |