Effect of CPAP Therapy on Molecular Breath Patterns in Patients With OSA

Effect of CPAP Therapy on Molecular Breath Patterns in Patients With OSA (BrOSA)

Determination of changes in molecular breath patterns in OSA patients, naïve for OSA treatment before and after one month of CPAP therapy by untargeted, secondary electrospray ionisation-high resolution mass spectrometry (SESI-HRMS). Furthermore, breath patterns will be assessed for correlation and association to clinical outcomes such as change in OSA severity, sleepiness, and blood pressure.

Inclusion Criteria:

• Recently diagnosed OSA (AHI ≥20/h)
• Patient is willing to start CPAP therapy
• ESS > 10 points
• 18 years or above

Exclusion Criteria:

• Moribund or severe disease prohibiting protocol adherence
• Use of oxygen therapy or home ventilation
• Physical or intellectual impairment precluding informed consent or protocol adherence
• Known malignancy, acute pulmonary disease, drug or alcohol abuse, known active inflammatory diseases (e.g. autoimmune disease), relevant congenital defects e.g. amino acid metabolism defect, relevant endocrinological disease, renal failure (GFR < 15 mL/min)
• Pregnant patients