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The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
This study will look at patients who are undergoing resection of a skull based meningioma, located in the frontal or temporal lobe, via craniotomy or via endoscopic endonasal approach. The study will compare cognitive function at baseline, at six weeks postoperatively and at one year postoperatively. The cognitive testing being done at baseline will be a clinical care set of assessments done by the speech language pathology team and will include the RBANS tests, the MoCA, PROMIS-29, and NeuroQOL-Cognitive Functions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meningioma Group | This group will include all patients in the study, regardless of location (frontal or temporal lobe) or surgical approach (endoscopic endonasal or craniotomy). Fifty patients will be included in the cohort |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Long-term Cognitive testing | Other | These patients will undergo their standard of care cognitive testing at baseline, six weeks post-operatively and one year post-operatively. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall cognitive function | Cognitive function will be compared at baseline and at one year post-operatively. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function based on surgical approach using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | Patients divided by approach and overall cognitive function will be evaluated. | 12 months |
| Cognitive function based on tumor location using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical comorbidities based on quality of life questionnaire PROMIS-29 | Assessment of preoperative and postoperative comorbidities and their effects on cognitive function post-operatively. Co-morbidities will be based on clinical outcomes evaluated by the primary investigator, co-investigators and the speech language pathology team. | 12 months |
Inclusion Criteria:
Exclusion Criteria:
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Patients between 18 years of age and 89 years of age will be eligible for this study. Patients undergoing a resection of a meningioma located in the frontal or temporal lobes via craniotomy or endoscopic endonasal surgery for clinical purposes will be included. Should a patient have a previous surgical removal of a meningioma, they will still be included. However, all patients having undergone previous radiation to the brain, for any reason, will not be included in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emma Kurtz, BS | Contact | (614) 685-4534 | Emma.Kurtz@osumc.edu | |
| Uchechi Okafor, BS | Contact | 614-293-4876 | Uchechi.Okafor@osumc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Daniel Prevedello, MD | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio State University Wexner Medical Center | Recruiting | Columbus | Ohio | 43210 | United States |
There will not be sharing of individual participant data with other researchers
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| ID | Term |
|---|---|
| D008579 | Meningioma |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D009380 | Neoplasms, Nerve Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009383 | Neoplasms, Vascular Tissue |
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Patients will be divided by tumor location and cognitive function will be evaluated. |
| 12 months |
| D008577 | Meningeal Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009422 | Nervous System Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |