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The present study is a prospective cohort study. The aim is to assess the relationship between the presence of cancer stem-cells (CSC) and the risk of relapse in patients with early and locally advanced adenocarcinoma and squamous cell carcinoma of the lung
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure to lung cancer stem cells | Genetic | The exposure to lung cancer stem cells was measure as the percentage of Aldehyde dehydrogenase (ALDH) on all viable cells extracted from surgically resected tumor specimens |
| Measure | Description | Time Frame |
|---|---|---|
| Relapse Free Survival | Days from lung cancer resection to relapse | Minimum follow-up time: 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent major lung resection by lateral thoracotomy or videothoracoscopic approach for stage I, II, or IIIA adenocarcinoma or squamous cell carcinoma of the lung (tumor, node, metastasis (TNM) staging system, eighth edition)
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| Name | Affiliation | Role |
|---|---|---|
| Uliano Morandi, MD | Azienda Ospedaliero-Universitaria di Modena | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliero-Universitaria di Modena | Modena | 41124 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35674389 | Derived | Masciale V, Banchelli F, Grisendi G, D'Amico R, Maiorana A, Stefani A, Morandi U, Stella F, Dominici M, Aramini B. Cancer Stem Cells and Cell Cycle Genes as Independent Predictors of Relapse in Non-small Cell Lung Cancer: Secondary Analysis of a Prospective Study. Stem Cells Transl Med. 2022 Aug 23;11(8):797-804. doi: 10.1093/stcltm/szac040. | |
| 35356974 |
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| Masciale V, Banchelli F, Grisendi G, D'Amico R, Maiorana A, Stefani A, Morandi U, Stella F, Dominici M, Aramini B. The Influence of Cancer Stem Cells on the Risk of Relapse in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: A Prospective Cohort Study. Stem Cells Transl Med. 2022 Mar 31;11(3):239-247. doi: 10.1093/stcltm/szab029. |
| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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