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This study is a case controlled analytical study that analyzes the relationship between levels of inflammatory markers with the type of brain tumor. Samples of 35 people were then categorized according to the variables above and analyzing to measure its significance
This study is a case controlled analytical study to find the relationship between levels of inflammatory markers in patients with brain tumors. Samples were collected from patients at Haji Adam Malik Hospital in Medan, then the patient's blood serum was taken to be checked for these variables. Sample collection began in March - September 2020. The sample obtained was 35 people who met the inclusion and exclusion criteria.
Inclusion criteria:
Exclusion criteria:
Samples were categorized based on demographic data (age and gender), then the samples were categorized based on the type of brain tumor suffered. Once categorized, the levels of inflammatory markers was examined. Specimens were taken from the patient's peripheral blood examination and analyzed in laboratorium. The results of these examinations are grouped on a nominal scale, and analyzed statistically.
Based on this analysis, it will be determined whether there is a significant relationship between levels of inflammatory markers in the incidence of brain tumors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meningioma Group | This group is based on the type of histopathology and MRI images that lead to a meningioma type brain tumor. After grouping, blood serum samples was collected to check the value of CRP, procalcitonin and NLR. The data were entered in a table and then compared with values from other types of brain tumors. |
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| Glioma Group | This group is based on the type of histopathology and MRI images that lead to a glioma type brain tumor. After grouping, blood serum samples was collected to check the value of CRP, procalcitonin and NLR. The data were entered in a table and then compared with values from other types of brain tumors. |
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| Brain Metastasis Group | This group is based on the type of histopathology and MRI images that lead to a metastasis brain tumor type After grouping, blood serum samples was collected to check the value of CRP, procalcitonin and NLR. The data were entered in a table and then compared with values from other types of brain tumors. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Procalcitonin | Diagnostic Test | Samples were categorized based on demographic data (age and gender), then the samples were categorized based on the type of brain tumor suffered. Once categorized, the levels of inflammatory markers was examined. Specimens were taken from the patient's peripheral blood examination and analyzed in laboratorium. The results of these examinations are grouped on a nominal scale, and analyzed statistically |
| Measure | Description | Time Frame |
|---|---|---|
| Value of Procalcitonin | Value of Procalcitonin in each group (Meningioma Group, Glioma Group and Brain metastasis group) | February-April 2020 |
| Value of C-Reactive Protein | Value of C-Reactive Protein in each group (Meningioma Group, Glioma Group and Brain metastasis group) | April- June 2020 |
| Value of Neutrophyl to Lymphocyte Ratio (NLR) | Value of NLR in each group (Meningioma Group, Glioma Group and Brain metastasis group) | June- August 2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Demographic of samples | Demographic of each samples such as age, gender, Glassgow coma scale and Karnofsky score | August- October 2020 |
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Inclusion Criteria:
Exclusion Criteria:
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Samples were collected from patients at Haji Adam Malik Hospital in Medan, Sample collection began in March - September 2020
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Universitas Sumatera Utara | Medan | North Sumatera | 20155 | Indonesia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12749651 | Background | Casado-Flores J, Blanco-Quiros A, Asensio J, Arranz E, Garrote JA, Nieto M. Serum procalcitonin in children with suspected sepsis: a comparison with C-reactive protein and neutrophil count. Pediatr Crit Care Med. 2003 Apr;4(2):190-5. doi: 10.1097/01.PCC.0000059420.15811.2D. | |
| 24202395 | Result | Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013 Nov;19(11):1423-37. doi: 10.1038/nm.3394. |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |