Prognostic Model of HCV-related Disease Progression After DAAs

Prognostic Model of HCV-related Disease Progression After DAAs

In this study, the investigator would conduct an ambispective cohort study to build a prediction model of HCV-related disease after DAAs.

The emergence of direct antiviral agents (DAAs) makes it possible to cure HCV, and the sustained virological response (SVR) rate is up to 90% after DAAs therapy. However, the acquisition of SVR does not mean the cure of HCV-related diseases, some patients still developed liver cirrhosis, liver cancer and other diseases after achived SVR by DAAs therapy.In this study the investigator would like to bulid a prediction model of HCV-related disease after DAAs by conducting an ambispective cohort study. The participants of this study would be adult patients (≥18 years old) with chronic HCV infection and have received DAA therapy, the investigator would retrospectively collected DAA therapy-related information, and follow-up all the enrolled participants every 6 months to observe their liver-related disease outcomes (composite liver outcome, including liver-related deaths, hepatocellular carcinoma, liver decompensation, and liver transplantation).

Inclusion Criteria:

• adult patients (≥18 years old) with chronic HCV infection that were HCV RNA positive;
• have received DAA treatment;
• would like to adhere to the follow-up

Exclusion Criteria:

• lack of HCV treatment information;