NOX4 and Related Biomarkers in ADPKD

NOX4, Mitochondria and Related Biomarkers in Autosomal Dominant Polycystic Kidney Disease

To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).

This will be a cross sectional study and will include male and female, young (15-40-years) well characterized patients with early (eGFR>70mL/min/1.73m2) ADPKD. Patients with different classes of disease severity will be selected using the ADPKD imaging classification. The study will include 60 class-1 (A-E) patients (N=12 per each sub-class).

Inclusion Criteria:

• ADPKD (based on Ravine et al. criteria)
• Class 1 A-E according to imaging classification
• Male and female subjects 15 - 40 years of age
• Estimated GFR> 70 mL/min/1.73 m2 (CKD-EPI)
• Ability to provide written, informed consent

Exclusion Criteria:

• Class 2 according to imaging classification
• Concomitant systemic disease affecting the kidney
• Diabetes mellitus
• Predicted urine protein excretion in >1 g/24 hrs
• Use of antioxidants i.e. vitamins, Nrf2 activators
• Abnormal urinalysis