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Erectile dysfunction (ED) is the persistent inability to attain and maintain a sufficient erection to permit satisfactory sexual performance. ED, a condition closely related to cardiovascular morbidity and mortality, is frequently associated with obesity. The importance of reducing cardiovascular risk factors remains fundamental to the overall vascular good health of the man, and that includes sexual vascular health. ED shares similar modifiable risks factors with coronary artery disease (CAD). Lifestyle modification that targets CAD risk factors may also lead to improvement in ED.
Sixty obese men with ED complaints will be divided to two groups, exercised and non-exercised groups; n= 30 patients in every group. Both groups will receive five milligrams of tadalafil one time per day for 8 weeks but the exercised group only will receive - in addition to tadalafil - combined continuous and interval aerobic training, 3 session weekly for 8 weeks after detecting their target heart rate via the cardiopulmonary exercise test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercised group | Experimental | .(n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, in addition to 3 sessions, per week, of combined continuous and interval aerobic exercise for eight weeks |
|
| non-exercised group | Active Comparator | (n=30) will be sedentary obese men with ED. All participants will receive only five milligrams of tadalafil, one time per day, for eight weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tadalafil 5Mg Tab + continuous and interval exercise | Other | (n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, in addition to 3 sessions, per week, of combined continuous and interval aerobic exercise for eight weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Five-Item Version of International Index of Erectile Function (IIEF-5) | It is a questionnaire of five questions to diagnose ED in male patients | It will be measured after eight weeks of training |
| Measure | Description | Time Frame |
|---|---|---|
| Triglycerides | It will be measured via a venous blood sample | It will be measured after eight weeks of training |
| High density lipoprotein | It will be measured via a venous blood sample |
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Inclusion Criteria:
Exclusion Criteria:
self-representation of gender identity
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Ismail, lecturer | Contact | 02 01005154209 | allooka2012@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ali Ismail, lecturer | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo Unoversity | Recruiting | Giza | Egypt |
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| ID | Term |
|---|---|
| D007172 | Erectile Dysfunction |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D012735 | Sexual Dysfunction, Physiological |
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| ID | Term |
|---|---|
| D000068581 | Tadalafil |
| ID | Term |
|---|---|
| D002243 | Carbolines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
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| Tadalafil 5Mg Tab | Drug | (n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, for eight weeks |
|
|
| It will be measured after eight weeks of training |
| Insulin | It will be measured via a venous blood sample | It will be measured after eight weeks of training |
| Fasting blood glucose | it will be measured via a blood glucose meter | It will be measured after eight weeks of training |
| The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance | HOMA-IR = [fasting insulin (μU/mL) × fasting glucose (mmol)]/22.5 | It will be measured after eight weeks of training |
| body mass index | It will be obtained by dividing the weight in Kilograms on the squared height in meter | It will be measured after eight weeks of training |
| systolic blood pressure | it will be measured by a manual sphygmomanometer | It will be measured after eight weeks of training |
| diastolic blood pressure | it will be measured by a manual sphygmomanometer | It will be measured after eight weeks of training |
| Waist circumference | it will be measured by inelastic tape at the umbilicus level | It will be measured after eight weeks of training |
| D052801 | Male Urogenital Diseases |
| D020018 | Sexual Dysfunctions, Psychological |
| D001523 | Mental Disorders |
| D026121 |
| Indole Alkaloids |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |