Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Peking University Sixth Hospital | OTHER |
| Wuhan Wuchang Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
This study is carried on in Wuchang Hospital in Wuhan, China. The investigators plan to recruit 80 patients with COVID-19 and 80 matched healthy control. Using the design of case-control study, the study aims to assess the neurocognitive functions such as executive function and attentional bias in recovered patients with COVID-19 under normal and stress conditions, and to analyze the influencing factors of neurocognitive functions, such as mental health conditions, inflammation indicators and cardiopulmonary function.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 | Recovered COVID-19 patients in Wuhan |
| |
| Healthy Control | Uninfected people in Wuhan |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trier Social Stress Test | Behavioral | 8-min oral calculation and 5-min speech |
|
| Measure | Description | Time Frame |
|---|---|---|
| working memory | assessed by the n-back task, including 0-back, 1-back and 2-back | 10 minutes |
| Cognitive flexibility | assessed by the trail-making task | 3 minutes |
| Inhibitory control | assessed by the stroop task | 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Attention Bias | assessed by the dot-probe task | 15 minutes |
| Serum TNFalpha | Concentration of serum TNFalpha in ng/ml will be assessed by ELISA |
| Measure | Description | Time Frame |
|---|---|---|
| Stress response indicator 1 | concentration of saliva cortisol stress, assessed by ELISA | Saliva samples will be colleted before stress, 0 minutes and 10 minutes after stress. |
| Stress response indicator 2 |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Recovered COVID-19 patients and uninfected residents in Wuhan
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ping Wu, Dr. | Contact | 861082802470 | 509 | wuping@bjmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Lin Lu, Dr. | National Institute on Drug Dependence, Peking University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wuhan Wuchang Hospital | Recruiting | Wuhan | Hubei | 430063 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
Not provided
Not provided
Not provided
Not provided
Not provided
| 1 day |
| Serum IL-6 | Concentration of serum IL-6 in ng/ml will be assessed by ELISA. | 1 day |
| CRP | hypersensitive C-reactive protein(hs-CRP) in mg/L will be assessed by Turbidimetric inhibition immuno assay. | 1 day |
| Depression | assessed by Self-Rating Depression Scale, which is consist of 20 items scoring 1 to 4. | 3-5 minutes |
| Anxiety | assessed by Self-Rating Anxiety Scale, which is consist of 20 items scoring 1 to 4. | 3-5 minutes |
| PTSD | assessed by PTSD Checklist for DSM-5 (PCL-5) | 3-5 minutes |
| Sleep | assessed by Pittsburgh sleep quality index (PSQI) | 3-5 minutes |
| General cognition | assessed by Montreal - Cognitive Assessment (MoCA) | 8-10 minutes |
| Cardiopulmonary function 1 | maximal inspiration pressure(MIP), maximal expiration pressure(MEP) | 15 minutes |
| Cardiopulmonary function 2 | Assessed by the 6-minutes' walk test | 10 minutes |
Hear rates
| Assessed before and 0 minute after stress |
| Stress response indicator 3 | Blood pressure before stress and after stress | Assessed before and 0 minute after stress |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |