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STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient satisfaction of the two modes of pregnancy, so as to better guide the clinical treatment.
400 patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy are intended to be enrolled. They are going to divided into two groups: PGS(preimplantation genetic screening) group and SP(spontaneous pregnancy) group. The pregnancy outcomes and offspring development of those patients will be followed up by our investigators.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PGS(Preimplantation Genetic Screening) | patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure |
| |
| SP(spontaneous pregnancy ) | patients with two times or more unexplained pregnancy loss, who wants to be pregnant via spontaneous pregnancy. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preimplantation Genetic Screening(exposure) | Procedure | Preimplantation genetic screening (PGS) was developed in the late 1980s as an alternative to prenatal diagnosis for couples at risk of transmitting a genetic or chromosomal abnormality to their children. In embryos created through in vitro fertilisation (IVF), cells are biopsied and analysed using genetic tests such as polymerase chain reaction and fluorescent in situ hybridisation (FISH). |
| Measure | Description | Time Frame |
|---|---|---|
| Live birth rate | the rate of the birth of a living fetus | 2 years of following up |
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Inclusion Criteria:
Exclusion Criteria:
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patients who seek treatment in our Recurrent Pregnancy Loss clinic.
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| Name | Affiliation | Role |
|---|---|---|
| Rong Li, M.D. | Center of Reproductive Medicine, Peking University Third Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center of Reproductive Medicine, Peking University Third Hospital | Beijing | Haidian | 100191 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27278003 | Background | Murugappan G, Shahine LK, Perfetto CO, Hickok LR, Lathi RB. Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss. Hum Reprod. 2016 Aug;31(8):1668-74. doi: 10.1093/humrep/dew135. Epub 2016 Jun 7. |
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