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This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.
This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Concept Retrieval | Experimental | Patients will be given behavioral intervention, and their brain activity recorded. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Concepts | Behavioral | Images and sounds that are characteristic of various common objects. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity | Electrocorticographic brain activity measured from brain surface | Recorded immediately during experiment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| William Gross, MD, PhD | Assistant Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 15, 2024 | |
| Reset | Sep 3, 2024 | |
| Release | Oct 10, 2025 | |
| Reset | Oct 24, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 15, 2024 | Sep 3, 2024 | |||
| Oct 10, 2025 |
| ID | Term |
|---|---|
| D001037 | Aphasia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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Present a behavioral intervention to a single group of participants and measure subsequent electrical activity in the brain.
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| Oct 24, 2025 |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |