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| Name | Class |
|---|---|
| Charite University, Berlin, Germany | OTHER |
| Hannover Medical School | OTHER |
| German Cancer Aid | OTHER |
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The primary objectives of this prospective observational multicenter study LUPE are to assess the prevalence of mental disorders according to the DSM-5 (objective need for psycho-oncological support), psychosocial distress, psycho-oncological care needs and utilization of psycho-oncological support services (subjective need for support) of cancer patients and their relatives during the first months of cancer survivorship stratified by biopsychosocial factors including socioeconomic status. The investigators further aim to identify moderating and mediating as well as associated factors for psychological distress and supportive care needs.
LUPE will include 2000 adult patients with solid tumor entities and one relative per patient at 4 measurement points from time of diagnosis to follow-up (+18 months) (t1: after diagnosis, t2: 6 month later, t3: 6 month later, t4: 6 month later).
The investigators aim to generate a quota sample according to socioeconomic status (SES) that is representative of the German overall population.
All participants will receive validated self-report questionnaires. Cancer patients will be interviewed using the standardized clinical interview SCID-5.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | |||
| Relatives |
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of mental disorders according to the DSM-5 (objective need for psycho-oncological support) in cancer patients and the changes over time | SCID (Structured Clinical Interview) | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) |
| Frequency and extent of psychological distress (Depression) (subjective psycho-oncological support needs) in cancer patients and their relatives and the changes over time | PHQ (Patient Health Questionnaire - Depression) | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) |
| Frequency and extent of psychological distress (Anxiety) (subjective psycho-oncological support needs) in cancer patients and their relatives and the changes over time | GAD (Generalized Anxiety Disorder) | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) |
| Use of psycho-oncological support services by patients and relatives and the changes over time | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) | |
| Changes in Quality of Life and the changes over time | EORTC (European Organisation for Research and Treatment of Cancer - Quality of life) | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) |
| Measure | Description | Time Frame |
|---|---|---|
| Protective factors and stress-increasing risk factors within the dyad of relatives and the changes over time | DCI (Dyadic Coping Inventar) | after the diagnosis (up to 8 weeks) and at every follow up (Month 6, Month 12, Month 18) |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence of the patients | AAQ (Adherence Assessment Questionnaire) | at follow up (Month 6) |
Inclusion Criteria:
Exclusion Criteria:
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Patients with solid oncological tumors diagnosed no more than 4-8 weeks ago and meeting the inclusion criteria. The relatives of the patients do not have to meet any special inclusion criteria.
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| Name | Affiliation | Role |
|---|---|---|
| Anja Mehnert-Theuerkauf, Prof | Universitätsklinikum Leipzig | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig | Leipzig | Saxony | 04103 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40747744 | Derived | Mehnert-Theuerkauf A, Goerling U, Zimmermann T, Ernst J, Hermann M, Hornemann B, Keilholz U, Lordick F, Knesebeck OVD, Kissane D, Koditz AK, Springer F. Early Cancer Survivorship Distress Trajectories Associated With Socioeconomic Status and Age: Findings From a Multicenter Prospective Study. Cancer Med. 2025 Aug;14(15):e71076. doi: 10.1002/cam4.71076. | |
| 37151329 |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D010342 | Patient Acceptance of Health Care |
| D001523 | Mental Disorders |
| ID | Term |
|---|---|
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| Mehnert-Theuerkauf A, Hufeld JM, Esser P, Goerling U, Hermann M, Zimmermann T, Reuter H, Ernst J. Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study). Front Psychol. 2023 Apr 20;14:1125545. doi: 10.3389/fpsyg.2023.1125545. eCollection 2023. |