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In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral globus palliotomy) and deep brain stimulation (unilateral globus pallidus) ,in order to get the conclusion of the comparison of the clinical efficacy of the two surgical plans. In addition, possible predictive factors such as age, gender, age of onset, length of disease course, scale baseline score, preoperative brain PET-CT function analysis and other possible predictive factors are added for analysis, in order to find predictive factors that can guide the choice of surgical options.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meige sydrome patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pallidotomy | Procedure | deep brain nuclei lesion of GPi |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Symptom | spasm of eyelid | 2 years |
| complications | Postoperative complications | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| quality of life | Evaluate using SF-36 | 2 years |
| depression scale | Evaluate using Hamilton Depression Scale | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Lack of incidence of Meige sydrome,and also lack of efficient of DBS or pallidotomy of Meige Syndrome. We try to collect more data as we can. We initially established a population of 100.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Beijing | China |
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| deep brain stimulation |
| Procedure |
deep brain stimulation of GPi |
|
| ID | Term |
|---|---|
| D008538 | Meige Syndrome |
| D008539 | Meigs Syndrome |
| C562467 | Lymphedema, Hereditary, II |
| D001764 | Blepharospasm |
| ID | Term |
|---|---|
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020821 | Dystonic Disorders |
| D009069 | Movement Disorders |
| D010051 | Ovarian Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |
| D005141 | Eyelid Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D053860 | Pallidotomy |
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D019635 | Neurosurgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
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