Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Oslo | OTHER |
Not provided
Not provided
Not provided
Not provided
Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Invasive cardiac electrophysiological study and ablation therapy | Procedure | Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation | ||
| Cardiopulmonary exercise testing | Diagnostic Test | Standard ergometer bicycle test | ||
| Cardiac MRI | Diagnostic Test | Cardiac MRI with cine-imaging and late-gadolinium enhancement | ||
| Holter monitoring | Diagnostic Test | 24h 5 lead or 12 lead ECG recording | ||
| Transthoracic echocardiography | Diagnostic Test | 2D echocardiography | ||
| Coronary angiography |
| Measure | Description | Time Frame |
|---|---|---|
| MRI-based evidence of structural heart disease | Evidence of structural heart disease from MRI compared to echocardiography | 3-5 years |
| PVC induction vs PVC/HR-relationship | Correlation of method for induction of PVCs during invasive procedure vs PVC/HR relationship during CPET | 3-5 years |
| EPS-based evidence of structural heart disease | Evidence of structural heart disease from invasive electrophysiology vs MRI and echo | 3-5 years |
Not provided
Not provided
Inclusion Criteria: Patients referred for PVC ablation
Not provided
Not provided
Patients referred to PVC ablation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mathis K Stokke, MD PhD | Contact | 90696883 | +47 | m.k.stokke@medisin.uio.no |
| Name | Affiliation | Role |
|---|---|---|
| Mathis K Stokke, MD PhD | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital | Recruiting | Oslo | 0672 | Norway |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Diagnostic Test |
Conventional invasive coronary angiography or CT angiography as indicated |
| ID | Term |
|---|---|
| D018879 | Ventricular Premature Complexes |
| ID | Term |
|---|---|
| D005117 | Cardiac Complexes, Premature |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D005080 | Exercise Test |
| D015716 | Electrocardiography, Ambulatory |
| D004452 | Echocardiography |
| D017023 | Coronary Angiography |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
| D004562 | Electrocardiography |
| D004568 | Electrodiagnosis |
| D018670 | Monitoring, Ambulatory |
| D008991 | Monitoring, Physiologic |
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D014463 | Ultrasonography |
| D000792 | Angiography |
| D011859 | Radiography |
Not provided
Not provided