This is a prospective, non-interventional registry and biorepository for patients with IBD. Longitudinal follow-up data is collected from both patients and their treating gastroenterologist during routine clinical encounters. The biorepository will consist of prospective collection of blood samples, tissue samples, and fecal samples for research purposes, while the participants are undergoing a clinically-indicated procedure (i.e. venipuncture for routine tests, IV catheter placement, and/or endoscopy). Participants may choose to provide any or all of the aforementioned information and/or samples.

Inclusion Criteria:

• Male or female, age 18 years or older
• Willing and able to provide written consent for participation in the registry and biorepository
• Patients with known or suspected inflammatory bowel disease

Exclusion Criteria:

• Patient is unable to comprehend and/or cooperate with study activities
• Patient is too ill to provide consent
• Coagulopathy that precludes safe biopsy of the bowel
• Comorbidity that precludes safe participation in endoscopic procedures

All adult patients with a diagnosis or suspected diagnosis of IBD made by the treating medical team will be considered for recruitment and enrollment. No special populations are targeted for accrual to this study.