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To clarify the effects of convalescent plasma therapy on SARS-CoV-2 negative conversion rate during hospital stay and 28-day mortality of severe and life-threatening COVID-19 patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| convalescent plasma therapy group | the patients received convalescent plasma therapy |
| |
| Control group | the patients with similar situation without convalescent plasma therapy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| convalescent plasma | Biological | convalescent plasma was get from the patients who recovery from COVID-19 |
|
| Measure | Description | Time Frame |
|---|---|---|
| 28-day mortality | the mortality from ICU admission to 28 days after admission | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| SARS-CoV-2 negative conversion rate | SARS-CoV-2 viral shedding | up to 60 days |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients with COVID-19 who were admitted to ICUs of the participating hospitals between January 1 to February 29, 2020 were screened.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongda Hospital, Southeast University | Nanjing | Jiangsu | 210009 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35783610 | Derived | Pan C, Chen H, Xie J, Huang Y, Yang Y, Du B, Qiu H. The Efficiency of Convalescent Plasma Therapy in the Management of Critically Ill Patients Infected With COVID-19: A Matched Cohort Study. Front Med (Lausanne). 2022 Jun 16;9:822821. doi: 10.3389/fmed.2022.822821. eCollection 2022. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |