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The present project aims at exploring different components of Self-consciousness or 'the Self', such as autobiographical memory, self-concept and subjective sense of Self, in dementia with Lewy Bodies (DLB) compared to Alzheimer's disease and to normal ageing. Anatomical substrates will be studied in multimodal imaging, in terms of volume, anatomical and functional connectivity. We expect to find an alteration of the different components of the Self, consecutive to insular dysfunction, a key region within cerebral networks of self-consciousness, which is damaged early in the course of the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dementia with Lewy bodies | Experimental |
| |
| Alzheimer disease | Active Comparator |
| |
| healthy elderly subjects | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological assessment and Multimodal brain MRI | Other | Neuropsychological assessment and Multimodal brain MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological assessment | months 3 | |
| Multimodal brain MRI | months 3 |
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Inclusion Criteria:
Inclusion criteria for all participants:
Inclusion criteria for group of dementia with Lewy bodies:
Inclusion criteria for group of Alzheimer disease:
Inclusion criteria for healthy elderly:
Exclusion Criteria:
Subjects with significant neuropsychiatric comorbidities
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| Name | Affiliation | Role |
|---|---|---|
| Nathalie PHILIPPI, MD | Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpitaux Universitaires de Strasbourg | Strasbourg | 67000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37106799 | Background | Tisserand A, Philippi N, Botzung A, Blanc F. Me, Myself and My Insula: An Oasis in the Forefront of Self-Consciousness. Biology (Basel). 2023 Apr 14;12(4):599. doi: 10.3390/biology12040599. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 6, 2026 | |
| Reset | Feb 25, 2026 | |
| Release | Jun 2, 2026 |
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| Reset | Jun 26, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 6, 2026 | Feb 25, 2026 | |||
| Jun 2, 2026 | Jun 26, 2026 | |||
| Jul 2, 2026 |
| ID | Term |
|---|---|
| D020961 | Lewy Body Disease |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D003704 | Dementia |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D024801 | Tauopathies |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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