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Because of the covid 19 pandemic, no patients were enrolled.
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This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.
The investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infants with febrile urinary tract infection | The investigators will recruit infants hospitalized for acute febrile urinary tract infection. Before starting antibiotics treatment, The investigators will collect feces with the informed consents from infants' parents. |
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| Healthy infants | The investigators will recruit healthy controls from the clinics for routine check up with the informed consents from infants' parents. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The collection of feces | Other | When the infants will be diagnosed with urinary tract infection, feces will be collected. Feces will be collected from healthy infants with informed consent. |
| Measure | Description | Time Frame |
|---|---|---|
| The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection. | The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2. From the OTU table, the investigators will conduct the differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection, using the linear discriminant analysis and analysis of differential abundance taking sample variation into account in R program and QIIME2. | An average of 1 year, after the completion of recruitment. |
| Measure | Description | Time Frame |
|---|---|---|
| The differential functional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection. | The investigators will predict the functional analysis from the OTU table and compare those results between healthy controls and infants with febrile urinary tract infection, using PICRUST2 analysis. | An average of 1 year, after the completion of recruitment. |
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Inclusion Criteria:
Exclusion Criteria:
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Infants hospitalized for febrile urinary tract infection. Healthy controls who visited at primary care clinic for routine check up with informed consent.
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| Name | Affiliation | Role |
|---|---|---|
| KY YOUNG CHO, M.D, Ph.D | Hallym University Kangnam Sacred Heart Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hallym University Kangnam Sacred Heart Hospital | Seoul | 07440 | South Korea |
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| ID | Term |
|---|---|
| D014552 | Urinary Tract Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces.
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |