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This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-Dose CT | Experimental | Low Dose CT Scan of the Chest |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low Dose CT | Diagnostic Test | All participants will have a low dose chest CT either within one year of enrollment or after enrollment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nodule detection rate | Frequency of nodule detection | 12 months |
| High-risk nodule detection rate | Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Interstitial lung disease detection rate | Frequency of interstitial lung disease detection | 12 months |
| Coronary artery calcification (CAC) ordinal scores | Frequency of high coronary artery calcification (CAC) ordinal scores. Possible scores range from 0 to 12 and high scores are defined as those greater than or equal to 10 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Erica T Warner, ScD | Massachusetts General Hospital | Principal Investigator |
| Lecia V Sequist, MD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| 12 months |
| D012140 |
| Respiratory Tract Diseases |