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| Name | Class |
|---|---|
| Medical Research Council | OTHER_GOV |
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An average of 4.8 million journeys are made on the London Underground every day and as the 'Tube' has elevated airborne particulate matter concentrations compared to ambient air, this raises concern about the potential health impact of this environment. This study explores the health effects of particulate matter from the London Underground on patients with COPD and healthy volunteers.
Patients with COPD and healthy participants will be invited to undertake a set 90 min journey on the London Underground, and on a separate occasion (3-8 weeks apart), a 90 min journey on the London Overground (as a proxy for a clean air London area while maintaining other aspects of a train journey). A series of clinical, physiological and inflammatory data will be collected before, during and after (at different time points) each of the sessions in order to compare their response in relation to exposure and/or to disease status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD patients | Experimental | As per inclusion and exclusion criteria for COPD patients |
|
| Healthy volunteers | Experimental | As per inclusion and exclusion criteria for healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure to London Underground ambient particulate matter | Other | Exposure to particulate matter on the London Underground |
|
| Measure | Description | Time Frame |
|---|---|---|
| The difference (London Underground vs control exposure) in post exposure pulse wave velocity in healthy vs COPD participants. | Measurement of arterial stiffness | -2 hours, +2 hours, +5 hours, +6 hours, +24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Other clinical responses on the London Underground vs control exposure | Symptom questionnaire | -2 hours, 0 hours, +45 minutes +90 minutes, +4 hours, +5 hours, +6 hours, +24 hours |
| Other clinical responses on the London Underground vs control exposure |
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Inclusion Criteria for both groups:
For participants with COPD:
For healthy volunteers:
Exclusion Criteria for both participants with COPD and healthy volunteers:
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| Name | Affiliation | Role |
|---|---|---|
| Frank Kelly | Imperial College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imperial Clinical Research Facility | London | W12 0HS | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29221643 | Background | Sinharay R, Gong J, Barratt B, Ohman-Strickland P, Ernst S, Kelly FJ, Zhang JJ, Collins P, Cullinan P, Chung KF. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. Lancet. 2018 Jan 27;391(10118):339-349. doi: 10.1016/S0140-6736(17)32643-0. Epub 2017 Dec 5. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 27, 2024 | |
| Reset | Nov 21, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 27, 2024 | Nov 21, 2024 |
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| Exposure to London air ambient particulate matter | Other | Exposure to ambient particulate matter on the London Overground (as a proxy as a proxy for a clean air London area while maintaining other aspects of a train journey) |
|
Spirometry (FEV1)
| -2 hours, 0 hours, +45 minutes, +90 minutes, +2 hours, +4 hours, +6 hours, +24 hours |
| Other clinical responses on the London Underground vs control exposure | Spirometry (FVC) | -2 hours, 0 hours, +45 minutes, +90 minutes, +2 hours, +4 hours, +6 hours, +24 hours |
| Other clinical responses on the London Underground vs control exposure | Spirometry (FEF 25-75) | -2 hours, 0 hours, +45 minutes, +90 minutes, +2 hours, +4 hours, +6 hours, +24 hours |
| Other clinical responses on the London Underground vs control exposure | Single breath transfer factor for carbon monoxide (TLCO) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (IL8) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (High sensitivity CRP) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (FBC) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (TNFa) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (vWf antigen) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (Thrombin generation (systemic inflammatory response)) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (8-isoprostanes (ELISA)) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (Blood malondialdehyde (lipid peroxidation)) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Blood sample (Oxidation Reduction Potential (oxidative stress)) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (IL-8) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (IL-6) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (IL-33) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (Myeloperoxidase) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (Neutrophil lipocalin-2) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (Tryptases) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (Complement) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (vWf antigen) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (Thrombin generation) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasosorption (D-dimer activation) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Nasal curettage (mRNA levels to elucidate molecular mechanisms that may explain the toxic effects of particulate matter) | -2 hours, +7 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Urine (8-isoprostane) | -2 hours, +24 hours |
| Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure | Urine (8-hydroxy 2-deoxyguanosine) | -2 hours, +24 hours |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |