Change in personnel and lack of resources to continue.

The purpose of this research study is to see if the level of serum ferritin differs based on how often oral iron (in the form of ferrous sulfate) is given to children with restless leg syndrome/periodic limb movement disorder.

Inclusion Criteria:

• Ferritin equal to or lower than 24 mcg/L drawn within the last 30 days.
• Age 2 to 10 years.
• Diagnosis of restless leg syndrome, periodic limb movement disorder, or sleep disturbance.

Exclusion Criteria:

• Currently taking oral formulation of iron other than a multivitamin.
• Untreated obstructive sleep apnea.
• Gastrointestinal disorder, including gastroesophageal reflux disease and celiac disease.
• Prior gastrointestinal surgery; e.g., gastrectomy, duodenal bypass, and presence of G-tube.
• Use of H2 blocker, antacid, or proton pump inhibitor.
• Inflammatory disorders, including juvenile idiopathic arthritis or inflammatory bowel disease.
• Elevated CRP at time of initial ferritin or report of illness in past 4 weeks.

Adverse events were collected from baseline to end of study participation for a total of approximately 2 months after starting ferrous sulfate on all participants.

Study terminated due to change in personnel and lack of resources to continue.