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The aim of this study is to investigate lower limb muscles after cerebrovascular accident
The aim of this study is to define and differentiate the changes in MMT properties related to the alterations in muscle tone of the lower limb in first-ever chronic stroke patients by using a 3D free-hand Ultrasonography (3DfUS) technique in combination with an instrumented spasticity assessment (IPSA). In these chronic stroke patients, the spontaneous neurological recovery is stabilized
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CVA and spasticity | Adults with first-ever chronic CVA and leg spasticity |
| |
| CVA without spasticity | Control group |
| |
| healthy subjects | Control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3DfUS and IPSA of leg muscles | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle volume | Estimation of muscle volume by 3D freehand ultrasonography. | 1 day |
| Muscle and Tendon Length | Estimation of muscle volume by 3D freehand ultrasonography | 1 day |
| Echogenicity intensity | Estimation of echogenicity intensity by 3D freehand ultrasonography on an 8-bit greyscale (256 values). | 1 day |
| Work [J] derived from the slow stretch | Measurement of Work [J] by Instrumented Spasticity Assessment | 1 day |
| Muscle activity EMG [uV] derived from the fast stretch | Measurement of Muscle activity EMG [uV] by Instrumented Spasticity Assessment | 1 day |
| Maximal velocity of performance (Vmax [deg/s]) | Measurement of Maximal velocity of performance (Vmax [deg/s]) by Instrumented Spasticity Assessment | 1 day |
| Range of motion [deg] for slow stretch | Measurement of Range of motion [deg] by Instrumented Spasticity Assessment | 1 day |
| Stiffness [Nm/deg] for slow stretch | Measurement of Stiffness [Nm/deg] by Instrumented Spasticity Assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical assessment of spasticity at fast stretch | Estimation of spasticity by Modified Assessment Scale | 1 day |
| Clinical assessment of spasticity angle at slow and fast stretch | Estimation of spasticity by Tardieu Scale |
| Measure | Description | Time Frame |
|---|---|---|
| Quantify the impairment caused by a stroke | Evaluation of impairment caused by stroke by National Institute Health Stroke Scale | 1 day |
| Assessments of functional independence in daily life in stroke patients and healthy subjects |
Inclusion Criteria:
Definition of case population :
o first ever stroke with spasticity of the lower limb.
Definition of control :
Exclusion Criteria:
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Adults with first ever chronic stroke:
= First ever stroke subjects with established spasticity and without spasticity will be recruited on the stroke rehabilitation unit and outpatient rehabilitation clinic, University Hospital of Leuven.
Healthy control subjects
= Healthy age-and gender matched subjects will be recruited among healthy university staff of the University Hospital of Leuven, their family and friends.
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| Name | Affiliation | Role |
|---|---|---|
| Fabienne Schillebeeckx, MD | UZ Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Leuven | Leuven | 3000 | Belgium |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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|
|
| 1 day |
| Joint angle of catch [deg] from the fast stretch | Measurement of Joint angle of catch [deg] from the fast stretch by Instrumented Spasticity Assessment | 1 day |
| Angle of EMG threshold [deg] from the fast stretch | Measurement of Angle of EMG threshold [deg] by Instrumented Spasticity Assessment | 1 day |
| Intensity of catch derived from the fast stretch | Measurement of Intensity of catch by Instrumented Spasticity Assessment | 1 day |
| 1 day |
Evaluation of functional independence in daily life is assessed by the Barthel Index
| 1 day |
| Assessments of functional status after stroke | Evaluation of functional status after stroke is assessed by the Functional Independence Measure | 1 day |
| Assessesment of mobility in stroke patients | Evaluation of mobility after stroke is assessed by the Rivermead Mobility Index | 1 day |
| Assessment of transfer skills in stroke patients and healthy subjects | Measurement of functional lower extremity strength and/or identify movement strategies in stroke patients and healthy subjects by The Five Times Sit to Stand Test | 1 day |
| Assessment of the motor impairment in lower limbs of stroke patients | Measurement of lower limb strength in stroke patients by the Motricity Index | 1 day |
| Assessments of gait speed analysis in stroke patients and healthy subjects. | 1 day | Measurement of gait speed in stroke patients and healthy subjects by 5-Meter Walk Test at comfortable or self-selected gait speed. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |