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| Name | Class |
|---|---|
| Centre Hospitalier Henri Duffaut - Avignon | OTHER |
| Assistance Publique Hopitaux De Marseille | OTHER |
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Patients affected by pheochromocytoma (PHEO) have brown-adipose tissue (BAT) hyperactivation. They perform, in routine settings, a FDG PET-CT scan. The high metabolic activity of BAT and its ability to consume both glucose and fatty acid suggest that it may have potential as a therapeutic target in the treatment of obesity. However, alternative non-invasive techniques to PET-CT BAT detection still need more validation. Accordingly, our aim will be to measure the temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test in PHEO patients.
Objectives and Methodology:
All the patients affected by will benefit from a:
Patients who will have surgery will be investigated before and after one year following resection of the tumor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BAT group | Experimental | Patients will be divided in two groups for statistical analysis:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Infrared themrography | Diagnostic Test | measurement of temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test |
| Measure | Description | Time Frame |
|---|---|---|
| Skin temperature in supra-clavicular region in basal condition (TSCRbasal) | Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) in basal condition | Day 0 |
| Skin temperature in supra-clavicular region during a cold test (TSCRcold) | Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) during a cold test (feet in water at 19°C during 20min) | Day 0 |
| Baseline difference in skin temperature in supra-clavicular region (diff TSCR) | diff TSCR (day 0) = TSCRcold - TSCRbasal | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Cutaneous blood flow in supra-clavicular region in basal condition (PUbasal) | Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) in basal condition | Day 0 |
| Cutaneous blood flow in supra-clavicular region during a cold test (PUcold) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Françoise Latil-Plat | Centre Hospitalier Henri Duffaut - Avignon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pôle ENDO- Hopital la Conception APHM | Marseille | PACA | 13385 | France |
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| ID | Term |
|---|---|
| D010673 | Pheochromocytoma |
| D010235 | Paraganglioma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) during a cold test (feet in water at 19°C during 20min) |
| Day 0 |
| Baseline difference in cutaneous blood flow in supra-clavicular region (∆PU) | diff PU (day0) =PUcold-PUbasal | Day 0 |
| Volume of Brown Adipose Tissue detected by PET-CT | 18FDG PET-CT will be performed and volume will be segmented by PET/CT Viewer.. | Day 0 |
| Activity of Brown Adipose Tissue detected by PET-CT | 18FDG PET-CT will be performed and BAT activity (Standardized Uptake Value (SUV) will be segmented by PET/CT Viewer.. | Day 0 |
| Change from baseline difference in skin temperature in supra-clavicular region ( ∆ diffTSCR) at 12 months | ∆ diff TSCR = diff TSCR(month12) - diff TSCR (day0) | Month 12 |
| Change from baseline difference in cutaneous blood flow in supra-clavicular region ( ∆ diff PU) at 12 months | ∆ diff PU = diff PU (month12) - diff PU (day0) | Month 12 |
| Volume of Brown Adipose Tissue detected by PET-CT | 18FDG PET-CT will be performed and volume will be segmented by PET/CT Viewer.. | Month 12 |
| Activity of Brown Adipose Tissue detected by PET-CT | 18FDG PET-CT will be performed and BAT activity (Standardized Uptake Value (SUV) will be segmented by PET/CT Viewer.. | Month 12 |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |