Hepatitis C Virus (HCV) Positive Kidney Grafts in HCV Negative Recipients

Transplantation of HCV Donor Kidneys in HCV Negative or Previously Successfully Treated Recipients

To determine the efficacy and safety of transplanting HCV positive kidney allografts to HCV sero-negative patients who are on the waiting list.

Inclusion Criteria:

• Male or female
• Age 18 and older
• English and Spanish speaking patients
• Active on the waiting list for kidney transplantation
• Donor organ with Antibody and NAT (nucleic acid test) positive for HCV
• HCV negative recipient; this includes patients who never had HCV and those with HCV previously eradicated with antiviral therapy. The latter is defined as those with undetectable HCV viral load at least 3 months since stopping therapy.
• Willing and able to provide written informed consent

Exclusion Criteria:

• Participants co-infected with HIV
• Donor previously treated with an NS5a containing regimen (if treatment history of donor known)
• Known allergies or hypersensitivity to DAA or RBV
• Pregnancy and/or actively breastfeeding