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| Name | Class |
|---|---|
| The Research Council of Norway | OTHER |
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Define a signature of gut microbiota composition and related metabolites in patients with ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic coronary disease (CAD).
A total of 200 patients, allocated to 50 patients with chronic coronary syndrome, 75 patients with non-ST elevation myocardial infarction and 75 patients with ST- elevation myocardial infarction will be included. Clinical information, blood samples and fecal samples will be collected. Fecal and blood samples will be collected once in patients With chronic disease and in patients with acute coronary syndrome; in the acute phase and after 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic coronary syndrome | 50 patients with chronic coronary disease | ||
| Non ST segment-elevation myocardial infarction | 75 patients with non ST-elevation myocardial infarction | ||
| ST-elevation myocardial infarction | 75 patients with ST segment-elevation myocardial infarction |
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| Measure | Description | Time Frame |
|---|---|---|
| Microbiota alpha diversity in myocardial infarction measured as Chao1 Index. | fecal-sample. 16srRNA (Miseq) will be used for sequencing. | Within 7 days from inclusion. |
| Microbiota alpha diversity in myocardial infarction measured as Chao1 Index | fecal-sample. 16srRNA (Miseq) will be used for sequencing. | At 3 months follow-up. |
| Lipopolysaccharide binding protein (LBP) in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion |
| Lipopolysaccharide binding protein (LBP) in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | Change from inclusion to 3 months follow-up. |
| Soluble cluster of difference-14 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion |
| Soluble cluster of difference-14 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | Change from inclusion to 3 months follow-up. |
| Intestinal fatty acid binding protein-1 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 20-75 years with coronary artery disease.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Geir Ø Andersen, MD.PhD | Contact | +4791502770 | g.o.andersen@medisin.uio.no |
| Name | Affiliation | Role |
|---|---|---|
| Marius Trøseid, Md Ass.prof | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology, Oslo University Hospital Ullevål | Recruiting | Oslo | N-0852 | Norway |
Study protocol, informed consent form (in Norwegian) and clinical study report will be shared by request.
Data become available 01.06.2022, and will be available until 01.06.2023.
Requests by email will be answered.
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D007410 | Intestinal Diseases |
| D000072657 | ST Elevation Myocardial Infarction |
| D000072658 | Non-ST Elevated Myocardial Infarction |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Blood, Peripheral blood mononuclear cells (PBMC), feces
| Intestinal fatty acid binding protein-1 in myocardial infarction |
Blood sample. Analyses will be performed with ELISA. |
| Change from inclusion to 3 months follow-up. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D009203 | Myocardial Infarction |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |