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Close monitoring of cardiac output (CO), especially in patients before and after intervention(such as volume expansion, diuresis, vasoconstriction, vasodilation therapy), could help to adjust the treatment strategy in cardiac surgical patients. Pulmonary artery catherization (PAC) has been used for hemodynamic monitoring for more than four decades. In spite of its invasiveness, it remains the clinical reference method for the assessment of CO at the bedside. Nowadays, many less invasive alternatives, such as LiDCO Rapid Pulse Contour Analysis System (LiDCO Ltd., Cambridge, United Kingdom), are already available on market. However, consistency between different hemodynamic monitoring results still raise concern. And whether hemodynamic monitoring could accurately detect the changes of these parameters before and after intervention is an important issue in clinical practice. In this study, the investigators are going to collect CO and changes of CO from PAC and LiDCO before and after intervention (passive leg raising and dobutamine stress test) in cardiac surgical patients. Our resulst could provide important reference for cardiac surgical patients how to choose appropriate hemodynamic monitoring tools and how to interpret the results of hemodynamic monitoring.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Passive Leg Raising | Experimental | Passive leg raising (PLR) test is used to predict fluid responsiveness, which is performed by raising the legs of the patient to 45°. Cardiac output will be collected from both PAC and LiDCO before and after PLR. |
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| Dobutamine stress test | Experimental | Dobutamine is a selective beta 1 receptor agonist. It [<10 ug/(kg.min)] can effectively increase myocardial contractility. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Passive Leg Raising | Diagnostic Test | Passive leg raising is induced by rasing the legs of patients to 45° from horizontal position. |
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| Measure | Description | Time Frame |
|---|---|---|
| Baseline Cardiac Output measurement | Cardiac Output measured at baseline position (horizontal position) | within1 minute at baseline position |
| Cardiac Output measurement after PLR | Cardiac Output measured after PLR | 1 minute after PLR |
| Cardiac Output measurement after Dobutamine stress test | Cardiac Output measured after dobutamine stress test | 5 minutes after dobutamine stress test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guo-wei Tu, Doctor | Contact | 86-021-64041990 | tu.guowei@zs-hospital.sh.cn | |
| Yijie Zhang, Doctor | Contact | 86-021-64041990 | zhang.yijie@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zhe Luo, Doctor | Fudan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 180 Fenglin Road | Recruiting | Shanghai | 200032 | China |
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| Dobutamine stress test | Diagnostic Test | Dobutamine was infused intravenously at the initial dose of 2.5 ug/kg/min. hemodynamic data were recorded from PAC and LiDCO after 5-10 minutes of continuous infusion. |
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