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| Name | Class |
|---|---|
| Karolinska University Hospital | OTHER |
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This study analyses clinical data prospectively collected for over a decade in several clinical databases. Electronic medical records are available since 1998.
Since 2011 the subgroup of patients that undergo fertility preservation are invited to participate in a prospective study aiming at long-term follow-up after fertility preservation for oncologic and non-oncologic conditions.
In this study, the investigators aim at analyze the treatment outcomes of patients with infertility, their clinical characteristics and biochemical parameters aiming at identifying predictors for the treatment outcomes.
For the cohort of patients that have undergone fertility preservation at Karolinska University Hospital, the investigators aim at investigating efficacy and safety of the procedures.
The data can be expanded by using additional databases such as the Regional Cancer Registry and other registries.
Analysis of data collected will allow the investigation of efficacy and safety of fertility preservation, identification of predictors for fertility outcomes,prediction of future activities and costs of the procedures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fertility preservation performed | subgroup analysis by cause of infertility, clinical characteristics, biochemical markers |
| |
| Fertility preservation not performed | subgroup analysis by cause of infertility, clinical characteristics, biochemical markers |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fertility preservation, several methods | Procedure | fertility preservation using assisted reproductive techniques or not |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy and safety of fertility preservation - Long-term follow-up | Correlation between method of fertility preservation and pregnacy rate | 2028 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcome of fertility treatments i breast cancer patients | Fertility treatment vs no fertility treatment i breastcancer patients: effect on survival | 5-20 years post diagnosis |
| Clinical outcome of fertility treatments i breast cancer patients |
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Inclusion Criteria:
Exclusion Criteria:
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Cohort collected from the registers of the university hospitals of Sweden, each representing a health care region, from 1995 and ongoing. FP is included in the tax funded healthcare system and data is registered all over the country. Date is also compared with the Swedish tax registry.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dan Grandér, Prof | Contact | dan.grander@ki.se | ||
| Susanne Gruber | Contact | susanne.gruber@ki.se |
| Name | Affiliation | Role |
|---|---|---|
| Dan Grandér, Prof | Karolinska Institutet | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Reproductive Medicine, Karolinska University Hospital | Recruiting | Stockholm | 141 86 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34277437 | Derived | Wikander I, Lundberg FE, Nilsson H, Borgstrom B, Rodriguez-Wallberg KA. A Prospective Study on Fertility Preservation in Prepubertal and Adolescent Girls Undergoing Hematological Stem Cell Transplantation. Front Oncol. 2021 Jun 30;11:692834. doi: 10.3389/fonc.2021.692834. eCollection 2021. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D059247 | Fertility Preservation |
| D015925 | Cryopreservation |
| D013514 | Surgical Procedures, Operative |
| ID | Term |
|---|---|
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D020858 | Tissue and Organ Harvesting |
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Fertility treatment vs no fertility treatment i breastcancer patients: effect on disease free survival
| 5-7 years post diagnosis |
| Predictors of effictive fertility treatment | Correlation between clinical variables (age, BMI, oocyte level, administered gonadotropins, infertility) method of fertility preservation and Pregnancy rate | patient data collected from time of treatment, pregnancy rate until end of study |
| Efficacy and safety of COS using GnRHa for fertility preservation in BC patients | hCG vs GnRH trigger on effect on number of cryopreserved embryos and oocytes | Observed outcomes in patients registered between 1995 and 2017. Follow up until end of 2018. |
| D014180 | Transplantation |
| D008919 | Investigative Techniques |
| D014021 | Tissue Preservation |
| D016591 | Histocytological Preparation Techniques |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
| D011309 | Preservation, Biological |