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Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation, metabolism independent of liver and kidney function, and no serious side effects, which has a good prospect for clinical application. Now we will study the effects of remimazolam on EEG and postoperative cognitive function ，in order to further understand the clinical application of remimazolam.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remimazolam 1 | Experimental |
| |
| Control | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia | Drug | remimazolam group was remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| The average intraoperative power spectral density in the frontal alpha band | EEG data were collected at the beginning of the room admission, and the collection was ended at the end of the operation. | Preoperatively, During operation，End of operation |
| Changes in the score of MMSE | The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery | The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in IL-6, IL-10, and S100-β levels | The outcome above should be measured the day before surgery and 1，3 days after surgery | The outcome above should be measured the day before surgery and 1，3 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Affiliated Hospital of Yangzhou University, Yangzhou University | Yangzhou | Jiangsu | China |
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| control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1 | Drug | control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1 |
|
| ID | Term |
|---|---|
| C522201 | remimazolam |
| D000768 | Anesthesia, General |
| D008874 | Midazolam |
| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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