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A multi-center, prospective,randomized, non-blind, controlled study was conducted to investigate the effects of different pre-operative nutritional support modes on perioperative nutritional status, surgical treatment success rate, and rehabilitation process in children with Hirschsprung disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention group | Experimental | Intravenous nutrition or oral high-calorie diet 7-10 days before surgery |
|
| control group | No Intervention | normal diet before surgery |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| supplement nutritional supporting | Dietary Supplement | Special medical formula for the purpose of formula food |
|
| Measure | Description | Time Frame |
|---|---|---|
| rate of postoperative HAEC | Incidence of postoperative HAEC | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Z score | weight/age | 3 months |
| LOS | length of postoperative stay | 1 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital | Wuhan | Hubei | 430000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41419466 | Derived | Zhang HY, Chen K, Zhang Y, Gao T, Huang Y, Ge L, Yuan Y, Zhang G, Yang H, Ren H, Zhan J, Xu W, Liu X, Zhu T, Feng J. Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial. Nat Commun. 2025 Dec 19;16(1):11171. doi: 10.1038/s41467-025-66541-x. |
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| ID | Term |
|---|---|
| D006627 | Hirschsprung Disease |
| ID | Term |
|---|---|
| D004065 | Digestive System Abnormalities |
| D004066 | Digestive System Diseases |
| D008531 | Megacolon |
| D003108 | Colonic Diseases |
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| reoperation |
rate of reoperation |
| 3 months |
| readmission | rate of readmission | 3 months |
| D007410 |
| Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |