The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.

The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.

The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.

Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.

Patients:

Inclusion criteria:

• Patients with moderate to severe tricuspid regurgitation
• Age ≥18 years
• Informed consent

Exclusion criteria:

• Reduced ejection fraction (<50%)
• Congenital heart disease
• Left sided valve disease
• MRI contraindications (All metal implants, cochlear implants, pacemakers etc.)
• Claustrophobia
• Peripheral edema
• BMI>30
• Age<18.

Controls:

Inclusion criteria:

• Healthy
• Age ≥18 years
• Age, gender and weight matched with included patients.

Exclusion criteria:

• Cardiovascular disease
• MRI contraindications (All metal implants, cochlear implants, pacemakers etc.)
• Claustrophobia
• Peripheral edema
• BMI>30
• Age<18.

Patients with moderate to severe tricuspid regurgitation and healthy, age, gender, and weight-matched controls