Assessing the Feasibility of N-of-1 Trials in Children With Hypertension and Chronic Kidney Disease

Assessing the Feasibility of N-of-1 Trials in Children With Hypertension and Chronic Kidney Disease: a Pilot Study

The purpose of this study to test whether n-of-1 trial-guided clinical decision-making improves blood pressure control in hypertensive children with chronic kidney disease (CKD) and end-stage renal disease (ESRD).

Inclusion Criteria:

• hypertension
• CKD stage 2-5
• requiring antihypertensive medication per clinician judgement.

Exclusion Criteria:

• renal transplant anticipated or occurred within 6 months of screening
• transfer out of our practice setting anticipated within 6 months
• unable to complete 24 hour arterial blood pressure monitoring (ABPM) due to developmental or behavioral limitations