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Objectives: To generate pilot data to investigate the feasibility and the potential use in clinical practice of technology based objective measures of motor performances in patients affected by different movement disorders. To correlate kinematics findings with demographic and clinical details. Trial design and methods: Participants enrolled in prof. Bhatia's movement disorders clinic, will be classifies according to the main movement disorder, specifically, tremor, parkinsonism, dystonia, chorea, ataxia. In the study visit (one day only), they will undergo a clinical evaluation using the appropriate clinical scales (respectively, Fahn-Tolosa-Marin tremor rating scale, MDS-UPDRS Part III, Toronto Western Spasmodic Torticollis Rating Scale 2, Unified Hungtington Disease Rating scale and Scale for the Assessment and Rating of Ataxia) and a kinematic evaluation, using wearables and an infra-red and LED markers system. Then the protocol is concluded and they will continue the routine clinical follow-up
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| kinematic analysis | Experimental | each patient with a diagnosis of parkinsonism, ataxia, chorea, dystonia or tremor will be asked to perform some motor tasks routinely used in clinical evaluation wearing inertial sensors. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| kinematic analysis | Device | motor tasks appropriate for each diagnosis will be recorder with wearable inertial sensors |
|
| Measure | Description | Time Frame |
|---|---|---|
| gait metrics | gait cycles measures (step length, phase duration, number of steps) practice of technology based objective measures of motor performances in patients affected by different movement disorders, to objectively evaluate the disease burden, the efficacy of therapeutic interventions and having a deeper phenotyping of motor disabilities. | up to 6 weeks after enrolment |
| tremor peak frequence | fourier analysis for peak frequence of tremor | up to 6 weeks after enrolment |
| neck ROM | range of motion of the neck in x,y and z axis | up to 6 weeks after enrolment |
| bradykinesia evaluation | amplitude of repeated limb movements over time | up to 6 weeks after enrolment |
| Measure | Description | Time Frame |
|---|---|---|
| correlation with UPDRS gait Item | correlation of gait metrics with UPDRS gait score included. | up to 6 weeks after enrolment |
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Inclusion Criteria:
clinical diagnosis of parkinsonism and/or dystonia and/or tremor due to:
18 to 80 years of age
Willing and able to provide informed consent
able to walk unassisted
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| kailash P Bhatia | Contact | 020 3448 4229 | k.bhatia@ucl.ac.uk | |
| giulia di lazzaro | Contact | 02034484229 | giulia.dilazzaro@nhs.net |
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| ID | Term |
|---|---|
| D009069 | Movement Disorders |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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