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To evaluate the effectiveness and safety of tacrolimus eye drops (FK-506) in the treatment of Posner-Schlossman Syndrome. It is expected to collect 30 patients with PSS who are in the Ophthalmology Department of Peking University Third Hospital. The included PSS patients were divided into experimental group and control group using simple randomization method. Among them, the experimental group was treated with FK-506 twice a day, and the control group was treated with prednisolone acetate ophthalmic suspension 1% 4 times a day.
For all PSS patients whose intraocular pressure is higher than 30mmHg, also add brinzolamide eye drops 3 times a day. Best corrected visual acuity, Goldmann intraocular pressure, anterior section photographs, corneal endothelial cells，corneal confocal microscope, Heidelberg retinal nerve analysis, Octopus visual field were examined on baseline and 1 week, 2 weeks, 3 weeks, 4 weeks after the treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The experimental group | Experimental |
| |
| The control group | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FK-506 (Drug) | Drug | Twice a day |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Silt-lamp examination of the cornea | KP numbers after the treatment | 1 week after the treatment |
| Silt-lamp examination of the cornea | KP numbers after the treatment | 2 weeks after the treatment |
| Silt-lamp examination of the cornea | KP numbers after the treatment | 3 weeks after the treatment |
| Silt-lamp examination of the cornea | KP numbers after the treatment | 4 weeks after the treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Goldmann ophthalmotonometer examination of intra-ocular pressure | change of intra-ocular pressure | 1 week after the treatment |
| Goldmann ophthalmotonometer examination of intra-ocular pressure | change of intra-ocular pressure |
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Inclusion Criteria:
- Clinical diagnosis of PSS Must be able to communicate with doctor and understand this study
Exclusion Criteria:
- Fuchs syndrome
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tingting Gao, PHD | Contact | 0086-13795176872 | gaotingting8139@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Chun Zhang, PHD,MD | Peking University Third Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hosipital | Recruiting | Beijing | Beijing Municipality | 100191 | China |
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| ID | Term |
|---|---|
| D016559 | Tacrolimus |
| D004364 | Pharmaceutical Preparations |
| C009935 | prednisolone acetate |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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| Prednisolone Acetate 1% Oph Susp | Drug | Four times a day |
|
| 2 weeks after the treatment |
| Goldmann ophthalmotonometer examination of intra-ocular pressure | change of intra-ocular pressure | 3 weeks after the treatment |
| Goldmann ophthalmotonometer examination of intra-ocular pressure | change of intra-ocular pressure | 4 weeks after the treatment |