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Purpose: The purpose of this article is to examine the clinical application of PRP and PRP+hyaluronic acid in disorders in the knee.
Methods:
The study was conducted on 150 adult patients with age over 20 years old affected by unilateral ACL complete tear and receiving ACL reconstruction. We divided the patients in three groups, and we treated the group A with perioperative injection of HHA, group B with perioperative HHA+PRP, group C with perioperative normal saline.
Follow-up:
Every 1,3,and 12months, we recheck physical exmianation at OPD and recheck MRI at postoperative 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group 1 | Experimental | Intraoperative1 kit of Platelet-rich plasma(PRP) injection into knee joint after anterior cruciate ligament (ACL) reconstruction. |
|
| Experimental group 2 | Experimental | Intraoperative1 kit of PRP+Hyaluronic acid(HA) injection into knee joint after ACL reconstruction. |
|
| Experimental group 3 | Placebo Comparator | Intraoperative 20 ml normal saline injection into knee joint after ACL reconstruction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RegenLab PRP | Combination Product | PRP preparations also improved functional outcome scores compared to hyaluronic acid and placebo in patients affected by knee osteoarthritis (OA). Based on previous studys, we can conclude that the PRP treatment is a safe and efficacious procedure which can provide functional benefit. |
| Measure | Description | Time Frame |
|---|---|---|
| 150 of participants with preoperative and postoperative physical examination are accessed by anterior drawer test and Lachman test | the investigators recheck physical exmianation of participants at OPD; physical examination was checked by one orthopedist | postoperative 1 month |
| 150 of participants with preoperative and postoperative physical examination are accessed by anterior drawer test and Lachman test | the investigators recheck physical exmianation of participants at OPD; physical examination was checked by one orthopedist | postoperative 3 months |
| 150 of participants with preoperative and postoperative physical examination are accessed by anterior drawer test and Lachman test | the investigators recheck physical exmianation of participants at OPD; physical examination was checked by one orthopedist | postoperative 12 months |
| 150 of participants with preoperative and postoperative Magnetic Resonance Imaging are accessed | anterior cruciate ligament was accessed by MRI T1 and T2 image; MRI was checked by one orthopedist | postoperative 3 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi Ping Wei, MD | Contact | +886-7-342-2121 | xgoznas22@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Ping Wei, MD | Kaohsiung Veterans General Hospital. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Veterans General Hospital | Recruiting | Kaohsiung City | Kaohsiung | 813 | Taiwan |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D000077324 | Crystalloid Solutions |
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|
| hyaluronic acid | Combination Product | Few studies investigated the effects of HA+PRP combined treatment for knee osteoarthritis (OA). Numerous studies demonstrated the efficacy of HA injection therapy in knee OA for a clinical point of view, reducing the pain and improving the quality of life. |
|
|
| normal saline | Other | In this study, we compare introperative PRP/PRP+HA/normal saline in ACL reconstruction patient. |
|
| D007552 |
| Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |