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| ID | Type | Description | Link |
|---|---|---|---|
| A176000 | Other Identifier | UW Madison | |
| EDUC/KINESIOLOGY | Other Identifier | UW Madison | |
| W81XWH1910381 | Other Grant/Funding Number | Department of Defense | |
| Protocol Version 09/15/2021 | Other Identifier | UW Madison |
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| Name | Class |
|---|---|
| United States Department of Defense | FED |
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Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
Gulf War Illness (GWI) is a multi-symptom illness with unknown etiology. GWI is a leading cause of disability in Gulf War Veterans. Cognitive complaints are a common symptom of GWI, which suggests the brain is involved in the development of this condition. As Veterans age, these cognitive complaints may worsen and be compounded by the aging process. GWI may be a condition of "accelerated" brain aging. Therefore, there may be long-term consequences of GWI, and the presence of GWI may increase a person's risk for developing Alzheimer's Disease (AD) or other dementias. In comparison to other brain-related diseases such as stroke, relatively little is known about GWI and how this condition impacts the normal age-related changes in the brain.
The research aims are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Veterans with GWI | Veterans with GWI who served in the Gulf War between 1990 and 1992 |
| |
| Veterans without GWI (Controls) | Veterans without GWI who served in the Gulf War between 1990 and 1992 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Device | Participants will undergo an MRI scan while participating in a breathing test to measure brain blood flow. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain blood flow measured using Transcranial Doppler ultrasound | Neurovascular control will be investigated by measuring the change in brain blood flow using a transcranial Doppler ultrasound in response to a breathing test. | Baseline |
| Brain blood flow measured using MRI | Neurovascular control will be investigated by measuring the change in brain blood flow using an MRI in response to a breathing test. | Baseline |
| Sympathetic nerve activity | Neurovascular control will be investigated by measuring the change in sympathetic nerve activity will be measured using microneurography in response to a breathing test. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects for this study will include Veterans with Gulf War Illness and Veterans without Gulf War Illness. Both men and women are eligible to participate in this study.
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| Name | Affiliation | Role |
|---|---|---|
| Jill N Barnes, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin-Madison | Madison | Wisconsin | 53706 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21272266 | Background | Lecrux C, Hamel E. The neurovascular unit in brain function and disease. Acta Physiol (Oxf). 2011 Sep;203(1):47-59. doi: 10.1111/j.1748-1716.2011.02256.x. Epub 2011 Mar 22. | |
| 30013388 | Background | Catchlove SJ, Parrish TB, Chen Y, Macpherson H, Hughes ME, Pipingas A. Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging. J Exp Neurosci. 2018 Jul 5;12:1179069518785151. doi: 10.1177/1179069518785151. eCollection 2018. |
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| ID | Term |
|---|---|
| D017585 | Ultrasonography, Doppler, Transcranial |
| ID | Term |
|---|---|
| D004453 | Echoencephalography |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
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| Transcranial Doppler Ultrasound | Device | Participants will undergo a TCD scan while participating in a breathing test to measure brain blood flow. |
|
| Sympathetic Nerve Activity | Other | Participants will undergo sympathetic nerve activity testing while participating in a breathing test. |
|
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| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |