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| Name | Class |
|---|---|
| Medi Image, Inc | UNKNOWN |
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Cerebral blood flow measurement, which is applied to patients with cerebrovascular-related diseases, provides useful information about hemodynamic status. There was a method using Doppler ultrasound and phase contrast (PC) MRI, but it was not widely used in clinical practice due to limitations in reproducibility between examiners, complexity of procedure, and time-intensive protocol. We intend to measure cerebral blood flow through the signal-intensity gradient (SIG) technique using Time-of-Flight (TOF) of brain magnetic resonance imaging, which can compensate for the shortcomings of the existing research methods. In addition, by analyzing the correlation with the previous methods, Doppler ultrasound and PC MRI, we will evaluate the effectiveness of our new method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects | Cerebral blood flow of a subject is measured using three methods in both common carotid and vertebral arteries. 1) Phase-contrast MR 2) Doppler sonography 3) Signal Intensity Gradient (SIG) To determine whether there is a correlation between the measured values, the correlation coefficient is calculated and analyzed. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Signal intensity gradient | Diagnostic Test | Signal intensity gradient: In time-of-flight (TOF) MRA, The signal intensities at the iso-point (Φa; signal intensity at position A [Xa] along the arterial contour line) and at the inner point (Φb; signal intensity at position B [Xb]) were calculated by using a trilinear interpolation algorithm based on the positions and signal intensities in the eight neighboring voxels. The signal intensities of TOF-MRA were normalized to eliminate the offset and scale effects across the MRA datasets of participants. For each iso-point (position A), the SIG was calculated from the difference in signal intensities between points A and B as follows: Scalar SIG, SI/mm = (Φb - Φa) / │Xb - Xa│ (1) Vector SIG, SI/mm = (Φb - Φa) n / │Xb - Xa│ (2) |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood flow correlation | Cerebral blood flow correlation between 3 tests (SIG, PC MR, US) | After completion of recruitment, average 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted to the neurology department of a tertiary center
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chan-Hyuk Lee, Prof. | Contact | +82-063-250-1590 | bluewave0210@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Chan-Hyuk Lee, Prof. | Jeonbuk National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jeonbuk National University Hospital | Recruiting | Jeonju | Jeollabuk-do | 54907 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28900625 | Background | Han KS, Lee SH, Ryu HU, Park SH, Chung GH, Cho YI, Jeong SK. Direct Assessment of Wall Shear Stress by Signal Intensity Gradient from Time-of-Flight Magnetic Resonance Angiography. Biomed Res Int. 2017;2017:7087086. doi: 10.1155/2017/7087086. Epub 2017 Aug 16. | |
| 31856692 | Background | Lee WJ, Jeong SK, Han KS, Lee SH, Ryu YJ, Sohn CH, Jung KH. Impact of Endothelial Shear Stress on the Bilateral Progression of Unilateral Moyamoya Disease. Stroke. 2020 Mar;51(3):775-783. doi: 10.1161/STROKEAHA.119.028117. Epub 2019 Dec 20. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 21, 2024 | |
| Reset | Dec 4, 2024 |
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| 24829599 | Background | Jeong SK, Lee JY, Rosenson RS. Association between Ischemic Stroke and Vascular Shear Stress in the Carotid Artery. J Clin Neurol. 2014 Apr;10(2):133-9. doi: 10.3988/jcn.2014.10.2.133. Epub 2014 Apr 23. |
| 41461703 | Derived | Lee CH, Lee SH, Kwak HS, Rosenson RS, Jeong SK, Jung KH. Arterial flow volume measurement using signal intensity gradient versus phase contrast. Sci Rep. 2025 Dec 29;15(1):44848. doi: 10.1038/s41598-025-28379-7. |
| 38332403 | Derived | Lee CH, Lee SH, Kwak HS, Kwak YG, Rosenson RS, Cho YI, Jeong SK. Validation of Signal Intensity Gradient from TOF-MRA for Wall Shear Stress by Phase-Contrast MR. J Imaging Inform Med. 2024 Jun;37(3):1248-1258. doi: 10.1007/s10278-024-00991-5. Epub 2024 Feb 8. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 21, 2024 | Dec 4, 2024 |