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| Name | Class |
|---|---|
| The Cooper Health System | OTHER |
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The increased prevalence of opioid use disorder (OUD) and associated overdoses and adverse events has led to a substantial increase in the number of patients being seen at emergency departments (ED). Thus, the ED may be an ideal location for identifying patients in need of OUD treatment and can serve as the first touch point in the OUD continuum of care to promote medication assisted treatment initiation. Contingency management (CM) is an effective method for promoting treatment initiation and adherence that has not been thoroughly evaluated for this purpose. The primary aim of the current study is to develop and assess the effectiveness, acceptability, and feasibility of a protocol for delivering CM to increase combined buprenorphine + nalaxone (referred to as BUP hereafter) initiation and continuous adherence for OUD in an existing ED "bridge" program (e.g., Bridge plus CM; B+CM) relative to standard care. Secondary objectives include identifying behavioral and neuropsychological correlates to treatment outcomes, including delay discounting, reinforcer demand, and neurological soft signs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contingency Management | Experimental | Participants in this arm of the study will receive financial incentives for attending their buprenorphine appointments and for being clean from other opioids. Participants in this group will also have up to two rides per week paid for to attend bup appointments. |
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| Standard Care | No Intervention | Participants in this group will be treatment as usual and will not receive any incentives for attending their bup appointments or for being opioid abstinent. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Contingency management | Behavioral | Financial incentives for attending bup appointments and demonstrating opioid abstinence. Rides will also be provided for up to two clinic visits per week. |
| Measure | Description | Time Frame |
|---|---|---|
| Attendance at first scheduled clinic appointment | We will track attendance at participant's first scheduled BUP appointment after being bridged from the ED | 1 week |
| Percentage of sessions where buprenorphine positive urine results was recorded | Urine-verified buprenorphine | 3-months |
| Percentage of sessions where opioid free urine results were recorded | Urine-verified opioid abstinence | 3-months |
| Treatment acceptability | Participants will evaluate the treatment at the end. | 3-months |
| Measure | Description | Time Frame |
|---|---|---|
| Delay discounting as a correlate of opioid-free urine test results and buprenorphine-positive results | Delay discounting will be evaluated, using the brief, five question delay discounting procedure and will be correlated with urine results determining opioid abstinence and buprenorphine adherence. | 3-months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cooper University Hospital | Camden | New Jersey | 08108 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41538228 | Derived | Goodwin SR, Kirby KC, Salzman MS, Raiff BR. Pragmatic and low-cost contingency management intervention increases buprenorphine treatment engagement: Randomized controlled trial. Exp Clin Psychopharmacol. 2026 Feb;34(1):68-77. doi: 10.1037/pha0000823. |
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We will share the data after we have completed the study and have published all of the outcomes. We will only share the data with qualified researchers who provide a written request with clear justification for their need to access the data.
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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Two group, randomized controlled trial.
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Participants will only told if they are assigned to the contingency management group because there are different procedures for those individuals. The care providers will not know which participants are in the control group but they may know when people are in the CM group because extra urine screens will be collected and they will be scheduled for rides.
| Opioid demand as a correlate of opioid-free urine test results and buprenorphine-positive results |
The opioid purchasing task will be used to evaluate opioid demand and will be correlated with urine results determining opioid abstinence and buprenorphine adherence. |
| 3-months |
| Substance-free activities as a correlate of opioid-free urine test results and buprenorphine-positive results | A modified Pleasant Events Scale survey will be used to evaluate access to, and enjoyment from, substance-free activities and the results will be correlated with urine results determining opioid abstinence and buprenorphine adherence. | 3-months |
| Neurological Soft Signs correlate with treatment success | Participants will complete a drawing task that has been correlated with other substance use treatment outcomes in the past. | 3-months |