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Adenoid tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of cells. The purpose of the study was to explore the correlation among ER stress and adenoid tissue disorders and to explain the structure of diseases related to the immune system.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic adenoiditis | Patients with hypertrophy and those out of hypertrophy were determined and those who had purulant rhinorrhea signs and rate of adenoids-choana below 50% were categorized that chronic adenoiditis. |
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| Adenoid hypertrophy | Patients who have snoring and those whose adenoid choana rate is greater than 50% were categorized that adenoid hypertrophy group. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adenoidectomy surgery | Procedure | All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of ER stress and apoptosis with chronic adenoiditis and adenoid hypertrophy | Our primary outcome was to evaluate providing that ER stress and apoptosis reaction performing in chronic adenoiditis and adenoid hypertropy, which is related with the immune system of children. | 2018-2019 (1 year) |
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Inclusion Criteria:
- Patients with the clinical diagnosis of chronic adenoiditis and adenoid hypertrophy.
Exclusion Criteria:
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This study was performed on 54 patients (28 male, 26 female) between the ages of 3 and 9 (mean 5) with the clinical diagnosis of chronic adenoiditis and adenoid hypertrophy and who underwent adenoidectomy due to either chronic adenoiditis or adenoid hypertrophy.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Selcuk University | Konya | Selcuklu | 42100 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10577791 | Background | Casselbrant ML. What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. Int J Pediatr Otorhinolaryngol. 1999 Oct 5;49 Suppl 1:S133-5. doi: 10.1016/s0165-5876(99)00147-0. | |
| 32996202 | Background | Li R, Wang Y, Chen P, Meng J, Zhang H. Inhibiting endoplasmic reticulum stress by activation of G-protein-coupled estrogen receptor to protect retinal astrocytes under hyperoxia. J Biochem Mol Toxicol. 2021 Feb;35(2):e22641. doi: 10.1002/jbt.22641. Epub 2020 Sep 29. |
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We will share study protocol after our article has been accepted for publication in a journal.
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Adenoid tissues were gathered in groups in accordance with their size and analyzed in regards to ER stress and apoptosis markers by Real-Time PCR and Western Blotting method.