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Polyethylene glycol (PEG) is one of the most common laxatives used in colonoscopy. However, 5 - 15% of patients can not complete the preparation due to its poor taste and large volume. So this study is aimed to explore the effect of antiemetics on abdominal discomforts associated with PEG.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Domperidone group | Experimental | Patients in Domperidone group took 10mg of domperidone 30min before PEG. |
|
| Sulpiride group | Experimental | Patients in Sulpiride group took 100mg of sulpiride 30min before PEG. |
|
| Control group | No Intervention | Patients in Control group followed the regular routine of 3L split-dose of PEG. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Domperidone | Drug | Domperidone and sulpiride are antiemetics that may be useful in preventing the PEG-related nausea and vomiting. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of the discomforts during bowel preparation | The primary endpoint of this study was the discomforts during bowel preparation such as nausea, vomit, abdominal fullness and pain. These symptoms were assessed as none, mild, moderate and severe. Patients with mild to severe symptoms were classified as presence of discomforts. | before colonoscopy |
| Measure | Description | Time Frame |
|---|---|---|
| The quality of bowel preparation assessed by Boston Bowel Preparation Scale | The secondary endpoint was the quality of bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS) during the withdrawal phase of colonoscopy. The BBPS uses a 0-3 points scale assessing the bowel preparation quality in 3 segments of the colon (the right, transverse and left colons). BBPS score ≥ 6 were defined as adequate bowel preparation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shengliang Chen, Dr | Contact | 02158752345 | slchenmd@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shengliang Chen | Recruiting | Shanghai | 200001 | China |
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| ID | Term |
|---|---|
| D004294 | Domperidone |
| D013469 | Sulpiride |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
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| sulpiride | Drug | Domperidone and sulpiride are antiemetics that may be useful in preventing the PEG-related nausea and vomiting. |
|
| during colonoscopy |
| D006574 |
| Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D001549 | Benzamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D001565 | Benzoates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |