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| Name | Class |
|---|---|
| Endocrinology Research Centre, Moscow | OTHER_GOV |
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Search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with diabetes mellitus type 1 (T1DM) | Experimental | Treatment by transplantation of fecal microbiota |
|
| Patient with diabetes mellitus type 2 (T2DM) | Experimental | Treatment by transplantation of fecal microbiota |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fecal microbiota | Other | Transplantation of fecal microbiota of healthy donor with normal body mass index |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in insulin sensitivity within FMT, 6 months after FMT] | participants will undergo euglycaemic glucose clamp study | 6 months after FMT |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elena Ilina, MD | Federal Research and Clinical Center of Physical-Chemical Medicine | Study Director |
| Marina Shestakova, MD | Endocrinology Research Centre, Moscow | Study Director |
| Elena Zhgun, PhD | Federal Research and Clinical Center of Physical-Chemical Medicine | Principal Investigator |
| Elena Pokrovskaya | Endocrinology Research Centre, Moscow | Principal Investigator |
| Igor Sklyanik | Endocrinology Research Centre, Moscow | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Endocrinology Research Centre, Moscow | Moscow | 117036 | Russia | |||
| Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow (FRCC PCM) |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000069467 | Fecal Microbiota Transplantation |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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Two obese patients selected according to the inclusion criteria will undergo fecal microbiota transplantation from a healthy donor with a normal body mass index against the background of glucose-lowering therapy
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| Moscow |
| 117312 |
| Russia |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |