Pivotal Test: WB001

Postpartum Depression Pivotal Test: Randomized Clinical Trial of WB001

The purpose of the present randomized controlled study is to investigate if there is a difference in postpartum depression symptoms among participants assigned to :

1. an automated conversational agent based on the most researched and scientifically validated psychotherapies, primarily Cognitive Behavioral Therapy (CBT), and accessible via an iOS and Android application, or to
2. a comparison condition without CBT and conversation, though still delivered in an interactive smartphone application that is accessible anytime of day.

Inclusion Criteria:

• Women aged 18-45 years who had onset of a major depressive episode within the third trimester of pregnancy or within 4 weeks following delivery as measured by the MINI (Mini International Neuropsychiatric Interview).
• Current mild-moderate depression as measured by the HAM-D (HAM-D score>13 and <24)
• Women were </= to 6 months postpartum at the time of screening
• Owns a smartphone (Anrdroid or iOS smartphone with a recent, supported operating system)
• Available and committed to engage with the program and complete assessments for a 3-month duration
• Able to read and write in English
• U.S. resident

Exclusion Criteria:

• HAM-D score ≥ 24 (severe depression)
• Active psychosis
• Suicidal attempt or ideation with a plan and intent to harm oneself during the current episode of PPD
• History of (a) drug and/or alcohol abuse within the past 12 months (determined by self-report)
• Current pregnancy or plans to become pregnant within the next 4 months
• Fetal demise within the past 24 months
• Previous Woebot user