The aims of this study were to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques and to model the potential effect of different diagnostic techniques on S. aureus detection in orthopaedic patients

Inclusion Criteria:

• All patients undergoing primary total knee or total hip arthroplasty at our institution will be eligible.

Exclusion Criteria:

• Patients included in other prospective studies

All patients undergoing primary total knee or total hip arthroplasty at our institution will be eligible