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The purpose of this study to age-related differences to the response of a combined pituitary stimulation test with TRH, LHRH and ACTH.
Participants will be recruited in three different age intervals: 18-45 years, 55-80 years and 80+ years. These participants will all undergo the same stimulation test with 0.1 mg LHRH, 0.2 mg TRH, and 0.25 mg ACTH (Synachten). The tests will be perfomed at the same time of day for all particpants (between 08:15 and 08:45) and participants will be fasting for the test. Blood samples will be taken just before and at 10, 20, 30, 45, 60, 90 and 120 minutes following the stimulation test. Serum from blood samples will be stored at -20 degrees until analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young participants | 18-45 years old |
| |
| Old participants | 55-80 years old |
| |
| Oldest old participants | over 80 years old |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pituitary stimulation test | Diagnostic Test | Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in area under the curve in TSH. | Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period. | Immediately after procedure. |
| Differences in area under the curve in Prolactin. | Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period. | Immediately after procedure. |
| Differences in area under the curve in LH. | Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period. | Immediately after procedure. |
| Differences in area under the curve in FSH. | Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period. | Immediately after procedure. |
| Differences in area under the curve in Cortisol. | Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period. | Immediately after procedure. |
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| Measure | Description | Time Frame |
|---|---|---|
| Differences in peak values in TSH | Both absolute peak values and peak values relative to basal level will be calculated. | Immediately after procedure. |
| Differences in peak values in Prolactin | Both absolute peak values and peak values relative to basal level will be calculated. |
Inclusion Criteria:
Exclusion Criteria:
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Adults across different age groups without conditions affecting pituitary function. Minimum sample size has been determined by power calculation to be 15 participants. The study aims to include up 24 particpants to increase power in the primary analysis.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Geriatric Medicine, Aalborg University Hospital | Aalborg | Northen Jutland | 9000 | Denmark |
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| ID | Term |
|---|---|
| D010900 | Pituitary Diseases |
| ID | Term |
|---|---|
| D007027 | Hypothalamic Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Serum and urine samples
| Immediately after procedure. |
| Differences in peak values in LH | Both absolute peak values and peak values relative to basal level will be calculated. | Immediately after procedure. |
| Differences in peak values in FSH | Both absolute peak values and peak values relative to basal level will be calculated. | Immediately after procedure. |
| Differences in peak values in Cortisol | Both absolute peak values and peak values relative to basal level will be calculated. | Immediately after procedure. |
| Differences in time to peak for TSH. | Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test. | Immediately after procedure. |
| Differences in time to peak for Prolactin. | Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test. | Immediately after procedure. |
| Differences in time to peak for LH. | Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test. | Immediately after procedure. |
| Differences in time to peak for FSH. | Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test. | Immediately after procedure. |
| Differences in time to peak for Cortisol. | Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test. | Immediately after procedure. |
| D004700 | Endocrine System Diseases |