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This study investigates the association between level of suPAR and valvular heart disease in patients who have severe aortic stenosis or severe aortic regurgitation using commercially available suPARnostic standard enzyme-linked immunosorbent assay (ViroGates, Denmark)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with severe aortic stenosis or severe aortic regurgitation | Patients with severe aortic stenosis or severe aortic regurgitation |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with adverse clinical outcomes | Composite of all-cause death, cardiovascular mortality, and worsening of kidney function | Immediate post operation |
| Number of participants with adverse clinical outcomes | Composite of all-cause death, cardiovascular mortality, and worsening of kidney function | 2 years after recruiting |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with severe aortic stenosis or severe aortic regurgitation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jiwon Seo | Contact | 82-2-2228-8464 | jiwonseo1430@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28359415 | Background | Koller L, Stojkovic S, Richter B, Sulzgruber P, Potolidis C, Liebhart F, Mortl D, Berger R, Goliasch G, Wojta J, Hulsmann M, Niessner A. Soluble Urokinase-Type Plasminogen Activator Receptor Improves Risk Prediction in Patients With Chronic Heart Failure. JACC Heart Fail. 2017 Apr;5(4):268-277. doi: 10.1016/j.jchf.2016.12.008. | |
| 26539835 |
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| D001022 | Aortic Valve Insufficiency |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Serum
| Hayek SS, Sever S, Ko YA, Trachtman H, Awad M, Wadhwani S, Altintas MM, Wei C, Hotton AL, French AL, Sperling LS, Lerakis S, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Chronic Kidney Disease. N Engl J Med. 2015 Nov 12;373(20):1916-25. doi: 10.1056/NEJMoa1506362. Epub 2015 Nov 5. |
| 31995687 | Background | Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday MW Jr, Januzzi JL, Weisbord SD, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med. 2020 Jan 30;382(5):416-426. doi: 10.1056/NEJMoa1911481. |
| D014694 |
| Ventricular Outflow Obstruction |