PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

Inclusion Criteria:

• Age: >18 yo
• Gender: male or female
• Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke

Exclusion Criteria:

• 1) Planned surgical intervention
• 2) Severely abnormal blood glucose level (will be excluded from FDG PET imaging)
• 3) Unable to undergo CTP or PET imaging (i.e. claustrophobia)
• 4) Pregnancy