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| Name | Class |
|---|---|
| University of Vienna | OTHER |
| University Hospital Schleswig-Holstein | OTHER |
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This controlled interventional study will investigate the effects of a 12-weeks sport climbing course compared to 24 weeks of unsupervised physical exercise on motor symptoms in Parkinson's disease
The primary aim of this study is to evaluate the effects of a 12-week sport climbing course versus unsupervised physical exercise on motor symptoms in patients with Parkinson's disease.
Background: Sport climbing (SC) is known as a whole-body workout, which additionally trains cognitive, mental, and social abilities. In contrast to its public image, SC in a controlled environment using "top-rope" belay, is a safe sport and can be performed at any age and at any level. In the field of neurological rehabilitation, it is already used as "therapeutic SC" for other neurological diseases, such as stroke, multiple sclerosis, depressions etc. but studies on climbing in PD patients are lacking.
Hypothesis: to find significant improvement of motor symptoms in the climbing group compared to the control group as well as biopsychosocial improvements after 6 weeks, 12 weeks, and 6 months after the intervention.
Methods: Effects of SC on motor symptoms in 48 PD patients in total, who will be randomized into a climbing group (n=24) and a control group (n=24) will be evaluated. The climbing group will follow a 12-week 90 min/week climbing trainings course, led by professional climbing instructors.
The control group will receive education/information material of the European physiotherapy guidelines for physical activity recommended by the WHO and will be instructed to follow the recommendation of the guidelines to independently live an active lifestyle and train unsupervised. All patients will be evaluated with clinical assessments at baseline, in between the study period (mid), after completing the 12-weeks study period (post). As additional outcomes, health benefits of SC in PD with a holistic approach, covering biopsychosocial aspects will be investigated. Therefore, non-motoric and motoric parameters will be evaluated, and follow-up assessments 6 months after.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Climbing Group (CG) | Active Comparator | The patients in the Climbing Group (CG) followed a 12-weeks long climbing trainings course in small groups of 3-4 participants with a certified climbing instructor. |
|
| Unsupervised active group (UAG) | Active Comparator | The patients in the unsupervised activity group (UAG) received education European physiotherapy guidelines for physical activity recommended by the WHO of recommended activity and followed their self-selected activities over 12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Climbing | Other | The patients in the Climbing Group (CG) followed a 12-weeks long climbing trainings course in small groups of 3-4 participants with a certified climbing instructor. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Rating | Motor Part of the Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) III | Testpoints: Change from Baseline Score after 12 weeks of the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Gait and Balance using wearable sensors | Inertial Sensors will be used to quantify gait metrics (postural sway, gait cycle, speed) as participants conduct walking and balance trials | Testpoints: Change after 12 weeks of the intervention |
| Quantified Bradykinesia test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna, Department of Neurology | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38678241 | Derived | Langer A, Hansen C, Roth D, Santer A, Flotz A, Gruber J, Wizany L, Hasenauer S, Pokan R, Dabnichki P, Treven M, Zimmel S, Schmoeger M, Willinger U, Gassner L, Brucke C, Maetzler W, Zach H. Vertical locomotion improves horizontal locomotion: effects of climbing on gait and other mobility aspects in Parkinson's disease. A secondary analysis from a randomized controlled trial. J Neuroeng Rehabil. 2024 Apr 27;21(1):63. doi: 10.1186/s12984-024-01363-4. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D000072799 | Stair Climbing |
| ID | Term |
|---|---|
| D016138 | Walking |
| D008124 | Locomotion |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
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The participants were randomly assigned to either the climbng group or the unsupervised active group
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Movement disorder specialists who performed the MDS-UPDRS III ratings were blinded to the group assignment.
| Unsupervised activity group | Other | The patients in the unsupervised activity group (UAG) received education European physiotherapy guidelines for physical activity recommended by the WHO of recommended activity and followed their self-selected activities over 12 weeks. |
|
Changes in a quantified bradykinesia Tests by using a standardized speeded keyboard tapping task. Changes will be evaluates in keys/second |
| Testpoints: Change after 12 weeks of the intervention |
| Hand grip strength | Assessment of hand grip strength, using a dynamometer. Results will be evaluated in Kilogramms | Testpoints: Change after 12 weeks of the intervention |
| Parkinson Quality of Life Questionaire-39 (PDQ-39) | Quality of life, assessed by the PDQ-39 Questionnaire | Testpoints: Change after 12 weeks of the intervention |
| Social Outcomes | Questionnaiers about social effects | Testpoints: Change after 12 weeks of the intervention |
| Cognitive assessments | Change in cognition will be assessed using a standardized cognitive assessment battery, measuring following domains: executive functions, memory, attention and verbal functions | Testpoints: Change after 12 weeks of the intervention |
| Changes in brain functional and structural MRI (resting state paradigma) and Changes in brain structural and functional MRI | Changes in structural and functional MRI (resting state paradigma) will be assessed | Testpoints: Change after 12 weeks of the intervention |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D055687 |
| Musculoskeletal and Neural Physiological Phenomena |
| D015444 | Exercise |
| D009043 | Motor Activity |