The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.

Inclusion Criteria:

• Women aged ≥ 18 and ≤ 50 years
• Premenopausal
• Endometrioid histological diagnosis
• Scheduled for surgical intervention at MSKCC
• FIGO grade 1-2, clinical stage I
• Disease confined to uterus, no clear evidence of deep (≥50%) myoinvasion on imaging (MRI preferred, ultrasound optional)
• Normal ovaries on preoperative imaging
• Able to provide informed consent
• English-speaking

Exclusion Criteria:

• Known Lynch syndrome
• Prior bilateral oophorectomy
• Personal history of hormone receptor-positive breast carcinoma
• Increased risk of ovarian cancer identified on the basis of family or personal history
• Women currently on hormonal contraception, letrozole, or tamoxifen may not opt-in to AMH
• Women who recently underwent ovarian stimulation within the past 3 months may not opt-in to AMH
• Women who have pituitary dysfunction (or any pituitary disorders) may not opt-in to AMH
• Women who completed chemotherapy within <12 months may not opt-in to AMH

Patients will be recruited from the Gynecology Service, Department of Surgery, at MSK. All women undergoing surgery for endometrial cancer without clear preoperative suspicion for advanced-stage disease will be screened for participation in this study. No selectivity will be exercised by the investigators to minimize bias. The specific type of surgery for each patient, as well as its timing, will be determined by the treating gynecological surgeon.

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.