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| Name | Class |
|---|---|
| Universiteit Antwerpen | OTHER |
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Transcranial Direct Current Stimulation (tDCS) aims to induce cortical plasticity by modulating the activity of brain structures. The broad stimulation pattern, which is one of the main limitations of tDCS, can be overcome with the recently developed technique called High-Definition tDCS (HD-TDCS). The objective of the current study is to investigate the effect of HD-tDCS on tinnitus in a large patient cohort.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HD-tDCS | Experimental | Each patient received a total of six sessions of anodal HD-tDCS of right DLPFC. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Definition transcranial Direct Current Stimulation | Device | 1x1 tDCS low-intensity stimulator and 4x1 multichannel stimulation adaptor (Soterix Medical Inc, New York, NY) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Tinnitus Functional Index (TFI) | Tinnitus severity self-report questionnaire, ranging from 0-100 with a higher score representing a more severe tinnitus | Baseline (before intervention), immediately post intervention, 7 weeks follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Visual Analogue scale (VAS) for tinnitus loudness | Visual analogue scale measuring tinnitus loudness from 0-100, with a higher score representing a louder tinnitus Visual analogue scale measuring tinnitus loudness from 0-100, with a higher score representing a louder tinnitus | Baseline (before intervention), immediately post intervention, 7 weeks follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30019630 | Background | Jacquemin L, Shekhawat GS, Van de Heyning P, Mertens G, Fransen E, Van Rompaey V, Topsakal V, Moyaert J, Beyers J, Gilles A. Effects of Electrical Stimulation in Tinnitus Patients: Conventional Versus High-Definition tDCS. Neurorehabil Neural Repair. 2018 Aug;32(8):714-723. doi: 10.1177/1545968318787916. Epub 2018 Jul 18. | |
| 26180052 |
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| ID | Term |
|---|---|
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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| Change in Hospital Anxiety and Depression Scale (HADS) | Self-report questionnaire concerning anxiety and depression symptoms, ranging from 0-21 for each subscale. A result greater than 8 suggests the presence of a depression and/or anxiety disorder. Visual analogue scale measuring tinnitus loudness from 0-100, with a higher score representing a louder tinnitus | Baseline (before intervention), immediately post intervention, 7 weeks follow-up |
| Change in Tinnitus Questionnaire (TQ) | Tinnitus severity self-report questionnaire, ranging from 0-84 with a higher score representing a more distressing tinnitus | Baseline (before intervention), immediately post intervention, 7 weeks follow-up |
| Change in Hyperacusis Questionnaire (HQ) | Hyperacusis severity self-report questionnaire, ranging from 0-42 with a higher score representing a higher sensitivity to sounds. A score of 28 is the cut-off for auditory hypersensitivity. | Baseline (before intervention), immediately post intervention, 7 weeks follow-up |
| Shekhawat GS, Sundram F, Bikson M, Truong D, De Ridder D, Stinear CM, Welch D, Searchfield GD. Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief. Neurorehabil Neural Repair. 2016 May;30(4):349-59. doi: 10.1177/1545968315595286. Epub 2015 Jul 15. |
| 29127483 | Background | Shekhawat GS, Vanneste S. High-definition transcranial direct current stimulation of the dorsolateral prefrontal cortex for tinnitus modulation: a preliminary trial. J Neural Transm (Vienna). 2018 Feb;125(2):163-171. doi: 10.1007/s00702-017-1808-6. Epub 2017 Nov 10. |
| 35666538 | Derived | Cardon E, Jacquemin L, Schecklmann M, Langguth B, Mertens G, Vanderveken OM, Lammers M, Van de Heyning P, Van Rompaey V, Gilles A. Random Forest Classification to Predict Response to High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief: A Preliminary Feasibility Study. Ear Hear. 2022 Nov-Dec 01;43(6):1816-1823. doi: 10.1097/AUD.0000000000001246. Epub 2022 Jun 7. |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |