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There is still no one who has studied how oral contraceptive use affects recovery in trained women after repeated high-intensity workouts. Consequently, a well-controlled study is needed.
The project is designed as a controlled cohort study, where 20 oral contraceptive users will be compared with 20 non-users. After initial preliminary examination and habituation to the test procedures, the subjects will start the intervention in week 2 of their menstrual cycle / active contraceptive pill cycle. Before and 3h, 24h and 48h after 3 intense strength training sessions performed 2 days in a row, blood samples will be taken, muscle soreness measured and performance tests performed. The day before the first training session and over the 4 trial days, the subjects will receive a standardized diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral contraceptive users | Experimental |
| |
| Non-oral contraceptive users | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training | Procedure | Both groups will perform a standardized training protocol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in maximal knee extensor strength and Rate of force development | Measured in a Humac Norm dynamometer | Before, 3 hours , 24 hours and 48 hours after training |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Jumping performance | Jump height | Before, 3 hours , 24 hours and 48 hours after training. |
| Changes in Jumping performance | Power |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University, Department for Public Health, Section for Sport Science | Aarhus | 8000 | Denmark |
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We will compare the recovery in a group of oral contraceptive users to a group of women not using oral contraceptives
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| Before, 3 hours , 24 hours and 48 hours after training. |
| Changes in Jumping performance | modified reactive strength index | Before, 3 hours , 24 hours and 48 hours after training. |
| Changes in Jumping performance | leg stiffness | Before, 3 hours , 24 hours and 48 hours after training. |
| Changes in Wingate performance | Peak power and average power | Before, 3 hours , 24 hours and 48 hours after training. |
| Changes in Yoyo-intermittent recovery 1 performance | total length covered in the yo-yo test | Before, and 48 hours after training. |
| Changes in Leg press performance | Total reps performed at 80% of 1RM | Before, 3 hours , 24 hours and 48 hours after training. |
| Changes training volume | total volume performed during training (i.e set x reps x working weight) | Before, 3 hours , 24 hours and 48 hours after training. |
| Differences in knee laxity | Measured with a Lachmeter | Baseline |
| Changes in muscle soreness (VAS-score) | Subjects will raise and sit on a chair and immediately after answer a VAS-score (100mm line, from worst pain ever, to no pain at all.) | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | estradiol | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | testosterone | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | sex hormone-binding globulin | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | progesterone | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | follicle-stimulating hormone | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | luteinizing hormone | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | Creatine kinase | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | Lactate dehydrogenase | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | Myoglobin | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | Cortisol | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | C-reactive protein | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | tumor necrosis factor | Before, 3 hours , 24 hours and 48 hours after training |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | IL-6 | Before, 3 hours , 24 hours and 48 hours after training |