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to determine safety and efficacy of Tranexamic Acid in reducing blood loss during Myomectomy in our institution.
A double blinded randomized controlled trial in which cases were given 1000mg intravenous tranexamic acid into 1L of intravenous normal saline and control were given 10mls of placebo water for injection into same amount of intravenous fluid. outcome of both groups in terms of intraoperative blood loss, duration of surgery, postoperative packed cell volume and total blood loss with risk of blood transfusion were then determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A: Cases that had tranexamic acid infusion | Experimental | Group A had perioperative tranexamic acid infusion at the rate of 100mls per hour |
|
| Group B: Control | Placebo Comparator | control were given perioperative placebo at the rate of 100mls per hour |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid | Drug | intravenous perioperative tranexamic acid was added into infusion of normal saline for the cases while placebo of intravenous water for injection was added into normal saline perioperatively for control |
| Measure | Description | Time Frame |
|---|---|---|
| Average duration of surgery in each group | Average duration of Surgeries were calculated for each group | one year |
| Mean intraoperative Blood loss | The mean intraoperative blood loss was calculated for both groups | one year |
| Postoperative Haemoglobin concentration | Average Postoperative Haemoglobin concentration of both groups were determined | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Transfusion | Risk of Blood Transfusion of both groups were determined | One year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AEFUTHA | Abakaliki | Ebonyi State | 480213 | Nigeria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38283394 | Derived | Olaleye AA, Adebayo JA, Eze JN, Ajah LO, Anikwe CC, Egede JO, Ebere CI. Efficacy of Tranexamic Acid in Reducing Myomectomy-Associated Blood Loss among Patients with Uterine Myomas at Federal Teaching Hospital Abakaliki: A Randomized Control Trial. Int J Reprod Med. 2024 Jan 18;2024:2794052. doi: 10.1155/2024/2794052. eCollection 2024. |
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two groups comprising of cases and control
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double blind
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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